Waldron T, Rogers J
Palaeopathology Study Group, Institute of Archaeology, London, United Kingdom.
Am J Phys Anthropol. 1990 Sep;83(1):123-7. doi: 10.1002/ajpa.1330830114.
A case-control study was undertaken to generate some hypotheses concerning the etiology of sacroiliac fusion in a group of skeletons dating from the 18th and 19th centuries. Forty-one skeletons with fusion of the sacroiliac joint were compared with eighty-two adult skeletons without the condition. The sacroiliac joints were most frequently fused with bridging osteophytes and no preference for site or side of fusion could be detected. Except where there were other features in the skeleton suggestive of a sero-negative arthropathy, radiography demonstrated that there was no intra-articular ankylosis. We were able to confirm earlier observations that the condition is more prevalent in males and in older age-groups. The study also showed a significant association between sacroiliac fusion and the presence of diffuse idiopathic skeletal hyperostosis (DISH) and osteoarthritis of the spine but not for osteoarthritis at any other site. There was a highly significant association between sacroiliac fusion and the phenomenon that we refer to as "bone forming." We devised a series of bone-former scores and were able to show a significant excess of cases with high scores compared with the controls. This association persisted when allowance had been made for potential confounding factors such as DISH, osteoarthritis of the spine, and age.
开展了一项病例对照研究，以针对一组18和19世纪的骨骼中骶髂关节融合的病因提出一些假设。将41例骶髂关节融合的骨骼与82例未患此病的成年骨骼进行比较。骶髂关节最常因骨桥赘生物而融合，未发现融合部位或侧别存在偏好。除了骨骼中有其他提示血清阴性关节病的特征外，X线摄影显示不存在关节内强直。我们能够证实早期的观察结果，即这种情况在男性和老年人群中更为普遍。该研究还表明，骶髂关节融合与弥漫性特发性骨肥厚（DISH）和脊柱骨关节炎的存在之间存在显著关联，但与其他任何部位的骨关节炎无关。骶髂关节融合与我们称为“骨形成”的现象之间存在高度显著关联。我们设计了一系列骨形成评分，并能够显示与对照组相比，高分病例显著过多。在考虑了诸如DISH、脊柱骨关节炎和年龄等潜在混杂因素后，这种关联仍然存在。
