探索长链非编码 RNA 功能的研究策略。
The research strategies for probing the function of long noncoding RNAs.
机构信息
Key laboratory of Freshwater Aquatic Genetic Resources, Shanghai Ocean University, Ministry of Agriculture, Shanghai Ocean University, Shanghai 201306, China.
出版信息
Genomics. 2012 Feb;99(2):76-80. doi: 10.1016/j.ygeno.2011.12.002. Epub 2011 Dec 16.
Long noncoding RNAs (lncRNAs) represent a new frontier in molecular genetics and molecular biology. They have a tremendous potential for advancing our comprehensive understanding of biological processes in huma n health and disease. The transcripts of lncRNAs are easy to find, but sorting out what they do remains the biggest challenge in lncRNAs' research field. In the paper, we highlight recent progress regarding the methods to explore the roles of lncRNAs.
长链非编码 RNA（lncRNAs）代表了分子遗传学和分子生物学的一个新前沿。它们具有极大的潜力，可以促进我们对人类健康和疾病中生物学过程的全面理解。lncRNAs 的转录本很容易找到，但理清它们的功能仍然是 lncRNAs 研究领域的最大挑战。在本文中，我们重点介绍了探索 lncRNAs 作用的方法方面的最新进展。
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