Department of Exercise and Nutrition Sciences, School of Public Health, University at Buffalo, Buffalo, NY 14214, USA.
Physiol Behav. 2012 Mar 20;105(5):1140-7. doi: 10.1016/j.physbeh.2011.12.012. Epub 2011 Dec 22.
Cardiovascular reactivity is associated with carotid artery intima-media thickness as early as childhood. Excess cardiovascular responses relative to the metabolic demand during psychological stress have been proposed as a mechanism for this association. However, it is not known whether excess cardiovascular responses in relation to the metabolic demand correlate with carotid artery intima-media thickness as strongly as traditionally measured cardiovascular reactivity.
Fifty-four adolescents, ages 13-16 years completed a graded exercise test in 1 day and measures of psychological stress reactivity (star tracing, speech) on another day. Heart rate, systolic blood pressure, and oxygen consumption were measured on both days. On a third visit adolescents completed an ultrasound scan to measure carotid artery intima-media thickness.
Traditionally measured systolic blood pressure reactivity (β=0.30, p=0.02, R(2) increase=0.09) and excess systolic blood pressure (β=0.30, p=0.02, R(2) increase=0.08) while preparing a speech were associated with greater carotid artery intima-media thickness when controlling for demographic characteristics, fitness, and baseline systolic blood pressure.
This study adds to the growing body of literature showing a link between systolic blood pressure reactivity to acute psychological stress and carotid artery intima-media thickness in youth. This was the first study to demonstrate that systolic blood pressure in excess of the metabolic demand during psychological stress was also associated with carotid artery-intima media thickness.
心血管反应性早在儿童期就与颈动脉内膜中层厚度有关。有人提出，在心理应激期间，相对于代谢需求的过度心血管反应是这种关联的一种机制。然而，尚不清楚相对于代谢需求的过度心血管反应与传统测量的心血管反应性一样强烈地与颈动脉内膜中层厚度相关。
54 名年龄在 13-16 岁的青少年在一天内完成了分级运动测试，在另一天完成了心理应激反应性（星迹追踪、言语）的测量。在这两天都测量了心率、收缩压和耗氧量。在第三次就诊时，青少年完成了超声扫描以测量颈动脉内膜中层厚度。
传统测量的收缩压反应性（β=0.30，p=0.02，R²增加=0.09）和在准备演讲时的过度收缩压（β=0.30，p=0.02，R²增加=0.08）与控制人口统计学特征、健康和基线收缩压时，与颈动脉内膜中层厚度的增加有关。
这项研究增加了越来越多的文献表明，青少年急性心理应激时的收缩压反应性与颈动脉内膜中层厚度之间存在联系。这是第一项表明心理应激期间超过代谢需求的收缩压也与颈动脉内膜中层厚度相关的研究。
