Persson P B, Ehmke H, Köhler W W, Kirchheim H R
Department of Physiology, Ruprecht-Karls University of Heidelberg, Federal Republic of Germany.
Am J Physiol. 1990 Oct;259(4 Pt 2):H1050-5. doi: 10.1152/ajpheart.1990.259.4.H1050.
All physiological feedback systems (e.g., in arterial pressure control) tend to oscillate in a characteristic manner. Mechanoreceptors can effectively buffer resulting fluctuations in arterial blood pressure. In this study arterial and cardiopulmonary receptors were interrupted in eight conscious foxhounds by sectioning the afferent pathways to the central nervous system. In response, three major peaks were detected in the blood pressure power spectrum: in addition to the well-known rhythms reflecting heart rate and respiration, very slow oscillating waves with a cycle length of 20 +/- 4 min and a 10(5)-fold higher power than the other two waves were detected. The amplitude of these oscillations could exceed 100 mmHg. This peak was also identified under control conditions (at a cycle length of 21 +/- 4 min, n = 6); however, the relative power was greater than 10(3)-fold less with mechanoreceptors intact (P less than 0.001). Thus a major slow oscillating component of arterial pressure control has been identified. Normally, mechanoreceptors buffer the resulting waves of this oscillator. These very strong fluctuations may characterize an important feature of blood pressure regulation.
所有生理反馈系统（如动脉血压控制中的反馈系统）往往会以一种特定的方式振荡。机械感受器可以有效地缓冲动脉血压由此产生的波动。在本研究中，通过切断传入中枢神经系统的通路，在8只清醒的猎狐犬中阻断了动脉和心肺感受器。作为反应，在血压功率谱中检测到三个主要峰值：除了反映心率和呼吸的众所周知的节律外，还检测到周期长度为20±4分钟、功率比其他两个波高10^5倍的非常缓慢的振荡波。这些振荡的幅度可能超过100 mmHg。在对照条件下（周期长度为21±4分钟，n = 6）也识别出了这个峰值；然而，在机械感受器完整的情况下，相对功率要小10^3倍以上（P < 0.001）。因此，已经识别出动脉血压控制中的一个主要的缓慢振荡成分。正常情况下，机械感受器会缓冲这个振荡器产生的波动。这些非常强烈的波动可能是血压调节的一个重要特征。
