患者相关变量对氯氮平血药浓度的影响。
Influence of patient-related variables on clozapine plasma levels.
作者信息
Haring C, Fleischhacker W W, Schett P, Humpel C, Barnas C, Saria A
机构信息
Department of Psychiatry, Innsbruck University Hospital, Austria.
出版信息
Am J Psychiatry. 1990 Nov;147(11):1471-5. doi: 10.1176/ajp.147.11.1471.
The authors investigated the clozapine plasma levels of 148 psychiatric inpatients. Multiple regression analysis revealed a linear relationship between dose of clozapine and plasma concentrations. The analysis showed a significant influence of dose, sex, smoking, weight, and age on the plasma concentrations of clozapine under clinical conditions. These results remained significant when clozapine doses below 150 mg/day and above 500 mg/day were excluded from the analysis.
作者对148名精神科住院患者的氯氮平血浆水平进行了研究。多元回归分析显示氯氮平剂量与血浆浓度之间存在线性关系。该分析表明，在临床条件下，剂量、性别、吸烟、体重和年龄对氯氮平血浆浓度有显著影响。当分析中排除低于150毫克/天和高于500毫克/天的氯氮平剂量时，这些结果仍然显著。
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