Department of Nephrology, University of Queensland, Princess Alexandra Hospital, Brisbane, Queensland, Australia.
Nephrology (Carlton). 2012 Mar;17(3):294-9. doi: 10.1111/j.1440-1797.2011.01560.x.
The aim of this study was to develop a limited sampling strategy (LSS) for the simultaneous estimation of exposure to tacrolimus, mycophenolic acid and unbound prednisolone in adult kidney transplant recipients.
Tacrolimus, mycophenolic acid and unbound prednisolone area under the concentration-time curve profiles from 0 to 12 h post dose (AUC(0-12)) were collected from 20 subjects. Multiple linear regression analyses were performed to develop a LSS enabling the simultaneous estimation of exposure to all three drugs. Median percentage prediction error and median absolute percentage prediction error were calculated via jackknife analysis to evaluate bias and imprecision.
LSS showed superior ability to predict exposure compared with single concentration-time points. A LSS incorporating concentration measurements at 0.5 h (C(0.5)), 2 h (C(2)) and 4 h (C(4)) post dose displayed acceptable predictive ability for all three drugs.
This LSS may serve as a useful research tool for further investigation of the utility of concentration monitoring of these medications.
本研究旨在为成年肾移植受者建立一种同时估算他克莫司、吗替麦考酚酸和游离泼尼松暴露的时间有限采样策略（LSS）。
从 20 名受试者中采集了他克莫司、吗替麦考酚酸和游离泼尼松的 0 至 12 小时的浓度-时间曲线下面积（AUC（0-12））。通过 Jackknife 分析计算中位数预测误差和中位数绝对预测误差，以评估偏差和不精确性。
LSS 显示出优于单一浓度-时间点的预测能力。在 LSS 中，纳入了给药后 0.5 小时（C（0.5））、2 小时（C（2））和 4 小时（C（4））的浓度测量值，可用于所有三种药物的预测。
该 LSS 可作为进一步研究这些药物浓度监测实用性的有用研究工具。
