Mohit-Tabatabai M A, Hill G J, Raina S, Rush B F, Ohanian M
Surgical Service (112), Veterans Administration Medical Center, East Orange, New Jersey 07019.
Am J Surg. 1990 Oct;160(4):370-2. doi: 10.1016/s0002-9610(05)80545-8.
Sixty-three patients with advanced unresectable squamous cell carcinoma of the head and neck were treated with a combination of chemotherapy, radiation, and surgery. We observed a 75% response to neoadjuvant chemotherapy. The 5-year survival rate for all 63 patients was 20%, and only 3 patients were alive at 8 years. The 5-year survival rate for patients who completed the treatment plan and received chemotherapy, radiation, and surgery was 43% compared with 20% for those who had chemotherapy and radiation but refused surgery. Development of a second primary cancer was the cause of death in 62% of the patients who survived more than 24 months.
63例晚期不可切除的头颈部鳞状细胞癌患者接受了化疗、放疗和手术联合治疗。我们观察到新辅助化疗的缓解率为75%。63例患者的5年生存率为20%，仅3例患者在8年后仍存活。完成治疗计划并接受化疗、放疗和手术的患者5年生存率为43%，而接受化疗和放疗但拒绝手术的患者5年生存率为20%。在存活超过24个月的患者中，62%的患者死于第二原发性癌症。
