下丘脑肥胖综合征：CNS+B 细胞淋巴母细胞淋巴瘤的罕见表现。
Hypothalamic obesity syndrome: rare presentation of CNS+ B-cell lymphoblastic lymphoma.
机构信息
Section of Pediatric Hematology/Oncology, Riley Hospital for Children, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
出版信息
Pediatr Blood Cancer. 2012 Nov;59(5):930-3. doi: 10.1002/pbc.24058. Epub 2011 Dec 27.
Abstract
Hypothalamic obesity syndrome can affect brain tumor patients following surgical intervention and irradiation. This syndrome is rare at diagnosis in childhood cancer, but has been reported with relapse of acute lymphoblastic leukemia. Here we present a case of hypothalamic obesity syndrome as the primary presentation of a toddler found to have CNS+ B-cell lymphoblastic lymphoma. Cytogenetic studies on diagnostic cerebrospinal fluid revealed MLL gene rearrangement (11q23). Hyperphagia and obesity dramatically improved following induction and consolidation chemotherapy. We describe a novel presentation of hypothalamic obesity syndrome in CNS B-cell lymphoblastic lymphoma, responsive to chemotherapy.
摘要
下丘脑肥胖综合征可影响接受手术干预和放疗的脑肿瘤患者。这种综合征在儿童癌症的诊断中很少见，但在急性淋巴细胞白血病复发时已有报道。在这里，我们报告了一例以下丘脑肥胖综合征为主要表现的幼儿病例，该幼儿被诊断为中枢神经系统+B 细胞淋巴母细胞淋巴瘤。对诊断性脑脊液的细胞遗传学研究显示 MLL 基因重排（11q23）。诱导和巩固化疗后，贪食和肥胖显著改善。我们描述了中枢神经系统 B 细胞淋巴母细胞瘤中一种新的下丘脑肥胖综合征表现，对化疗有反应。
相似文献
1
Hypothalamic obesity syndrome: rare presentation of CNS+ B-cell lymphoblastic lymphoma.下丘脑肥胖综合征：CNS+B 细胞淋巴母细胞淋巴瘤的罕见表现。
Pediatr Blood Cancer. 2012 Nov;59(5):930-3. doi: 10.1002/pbc.24058. Epub 2011 Dec 27.
2
Persistent detection of a novel MLL-SACM1L rearrangement in the absence of leukemia.在没有白血病的情况下持续检测到新型 MLL-SACM1L 重排。
Leuk Res. 2010 Oct;34(10):1398-401. doi: 10.1016/j.leukres.2010.05.001.
3
Therapy-related B-lymphoblastic leukemia associated with Philadelphia chromosome and MLL rearrangement: Single institution experience and the review of the literature.与费城染色体和MLL重排相关的治疗相关B淋巴细胞白血病：单中心经验及文献综述
Pathol Int. 2015 Oct;65(10):536-40. doi: 10.1111/pin.12337. Epub 2015 Aug 11.
4
MLL duplication in a pediatric patient with B-cell lymphoblastic lymphoma.一名患有B细胞淋巴细胞白血病的儿科患者中的MLL基因重复。
J Pediatr Hematol Oncol. 2012 Apr;34(3):e120-3. doi: 10.1097/MPH.0b013e3182273b57.
5
Acute leukaemia and myelodysplastic syndromes with chromosomal rearrangement involving 11q23 locus, but not gene.伴有涉及11q23位点染色体重排但不涉及特定基因的急性白血病和骨髓增生异常综合征。
J Clin Pathol. 2017 Mar;70(3):244-249. doi: 10.1136/jclinpath-2016-203831. Epub 2016 Aug 5.
6
MLL-rearranged mixed phenotype acute leukemia masquerading as B-cell ALL.伪装成B细胞急性淋巴细胞白血病的MLL重排混合表型急性白血病
Leuk Lymphoma. 2017 Jun;58(6):1498-1501. doi: 10.1080/10428194.2016.1246728. Epub 2016 Oct 24.
7
A pediatric case of -rearranged B-lymphoblastic lymphoma treated with high-risk therapy.1例采用高危治疗方案治疗的重排B淋巴细胞淋巴瘤儿科病例。
Leuk Lymphoma. 2024 Jun;65(6):843-847. doi: 10.1080/10428194.2024.2315159. Epub 2024 Feb 19.
8
11q23/MLL rearrangements in adult acute leukemia.成人急性白血病中 11q23/MLL 重排。
Exp Oncol. 2021 Sep;43(3):229-233. doi: 10.32471/exp-oncology.2312-8852.vol-43-no-3.16495.
9
Differential expression of Ikaros isoforms in monozygotic twins with MLL-rearranged precursor-B acute lymphoblastic leukemia.Ikaros亚型在伴有MLL重排的前体B细胞急性淋巴细胞白血病单卵双胞胎中的差异表达。
J Pediatr Hematol Oncol. 2008 Dec;30(12):941-4. doi: 10.1097/MPH.0b013e318180bbf5.
10
Homozygous inv(11)(q21q23) and MLL gene rearrangement in two patients with myeloid neoplasms.两名骨髓肿瘤患者中的纯合性inv(11)(q21q23)及MLL基因重排
Int J Clin Exp Pathol. 2014 May 15;7(6):3196-201. eCollection 2014.
引用本文的文献
1
Role of epigenetic in cancer biology, in hematologic malignancies and in anticancer therapy.表观遗传学在癌症生物学、血液系统恶性肿瘤及抗癌治疗中的作用。
Front Mol Med. 2024 Sep 6;4:1426454. doi: 10.3389/fmmed.2024.1426454. eCollection 2024.
2
Obesity as a Prognostic Factor of Central Nervous System Relapse in Children with Acute Lymphoblastic Leukemia: A Single-Centre Study and Literature Review.肥胖作为急性淋巴细胞白血病患儿中枢神经系统复发的预后因素：一项单中心研究及文献综述
Evid Based Complement Alternat Med. 2022 Mar 21;2022:7783823. doi: 10.1155/2022/7783823. eCollection 2022.
3
Hypothalamic-Pituitary Disorders in Childhood Cancer Survivors: Prevalence, Risk Factors and Long-Term Health Outcomes.儿童癌症幸存者的下丘脑-垂体疾病：患病率、危险因素和长期健康结局。
J Clin Endocrinol Metab. 2019 Dec 1;104(12):6101-6115. doi: 10.1210/jc.2019-00834.
4
Primary Hypothalamic Lymphoma in an Adult Male: A Case Report and Literature Review.一名成年男性的原发性下丘脑淋巴瘤：病例报告及文献综述
Oman Med J. 2018 Jul;33(4):346-351. doi: 10.5001/omj.2018.63.
本文引用的文献
1
Hypothalamic obesity : The autonomic hypothesis and the lateral hypothalamus.下丘脑性肥胖：自主神经假说与外侧下丘脑。
Diabetologia. 1981 Mar;20(Suppl 1):366-377. doi: 10.1007/BF00254505.
2
Hypothalamic obesity: causes, consequences, treatment.下丘脑性肥胖：病因、后果与治疗
Pediatr Endocrinol Rev. 2008 Dec;6(2):220-7.
3
Review of physiology, clinical manifestations, and management of hypothalamic obesity in humans.人类下丘脑性肥胖的生理学、临床表现及管理综述
Pituitary. 2009;12(2):87-95. doi: 10.1007/s11102-008-0096-4.
4
Prevalence, clinical pattern, and outcome of CNS involvement in childhood and adolescent non-Hodgkin's lymphoma differ by non-Hodgkin's lymphoma subtype: a Berlin-Frankfurt-Munster Group Report.儿童和青少年非霍奇金淋巴瘤中枢神经系统受累的患病率、临床模式及转归因非霍奇金淋巴瘤亚型而异：柏林-法兰克福-明斯特集团报告
J Clin Oncol. 2007 Sep 1;25(25):3915-22. doi: 10.1200/JCO.2007.11.0700.
5
The impact of the methotrexate administration schedule and dose in the treatment of children and adolescents with B-cell neoplasms: a report of the BFM Group Study NHL-BFM95.甲氨蝶呤给药方案和剂量对儿童及青少年B细胞肿瘤治疗的影响：BFM组NHL-BFM95研究报告
Blood. 2005 Feb 1;105(3):948-58. doi: 10.1182/blood-2004-03-0973. Epub 2004 Oct 14.
6
Features of the metabolic syndrome after childhood craniopharyngioma.儿童颅咽管瘤后代谢综合征的特征
J Clin Endocrinol Metab. 2004 Jan;89(1):81-6. doi: 10.1210/jc.2003-030442.
7
Octreotide therapy of pediatric hypothalamic obesity: a double-blind, placebo-controlled trial.奥曲肽治疗小儿下丘脑性肥胖：一项双盲、安慰剂对照试验。
J Clin Endocrinol Metab. 2003 Jun;88(6):2586-92. doi: 10.1210/jc.2002-030003.
8
Risk factors for the development of obesity in children surviving brain tumors.脑肿瘤存活儿童发生肥胖的危险因素。
J Clin Endocrinol Metab. 2003 Feb;88(2):611-6. doi: 10.1210/jc.2002-021180.
9
Endocrine complications in pediatric patients with acute lymphoblastic leukemia.急性淋巴细胞白血病患儿的内分泌并发症
Blood Rev. 2002 Dec;16(4):225-43. doi: 10.1016/s0268-960x(02)00042-5.
10
Changes in body mass index and prevalence of overweight in survivors of childhood acute lymphoblastic leukemia: role of cranial irradiation.儿童急性淋巴细胞白血病幸存者的体重指数变化及超重患病率：头颅放疗的作用
Med Pediatr Oncol. 2000 Aug;35(2):91-5. doi: 10.1002/1096-911x(200008)35:2<91::aid-mpo1>3.0.co;2-g.
Zotero 插件