茶碱与沙丁胺醇口服与吸入治疗哮喘的比较。
Comparison of oral theophylline and salbutamol by inhalation in asthmatic patients.
机构信息
Respiratory Unit, Repatriation General Hospital, Concord, N.S.W. 2139, Australia.
出版信息
Br J Clin Pharmacol. 1976 Aug;3(4):591-4. doi: 10.1111/j.1365-2125.1976.tb04880.x.
The bronchodilator effects of 375 mg theophylline orally and 200 microg salbutamol by pressurized aerosol were compared in a randomized, cross-over, double-blind trial in fourteen asthmatic patients. The mean peak percentage FEV1 increase from control was 43.7% at 60 min after salbutamol and 30.3% at 180 min after theophylline. Salbutamol produced significantly greater bronchodilatation than theophylline for the initial 30 min (P < 0.01). Theophylline demonstrated a longer duration of action than salbutamol, with a significantly greater FEV1 response at 360 min (P < 0.02). There was no significant difference between the total effect of each drug for the 360 min period, as calculated by the areas under the respective FEV1 response curves.
在 14 名哮喘患者中进行了一项随机、交叉、双盲试验，比较了口服 375mg 茶碱和 200μg 沙丁胺醇气雾剂的支气管扩张作用。沙丁胺醇在给药后 60 分钟时的平均最大 FEV1 增加百分比为 43.7%，而茶碱在给药后 180 分钟时为 30.3%。沙丁胺醇在最初 30 分钟内产生的支气管扩张作用明显大于茶碱（P<0.01）。茶碱的作用持续时间长于沙丁胺醇，在 360 分钟时 FEV1 反应显著更大（P<0.02）。通过各自 FEV1 反应曲线下的面积计算，在 360 分钟期间，两种药物的总效应之间没有显著差异。
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