MRC Unit and University Department of Clinical Pharmacology, Radcliffe Infirmary, Woodstock Road, Oxford OX2 6HE.
Br J Clin Pharmacol. 1976 Dec;3(6):1045-51. doi: 10.1111/j.1365-2125.1976.tb00356.x.
Three cases are described in which renal failure was accompanied by a lowered apparent volume of distribution of digoxin. In two cases this resulted in frank digoxin toxicity and in one equivocal toxicity. In all three cases digoxin plasma levels were greater than 2 ng/ml. The possible causes of the abnormal distribution of digoxin in renal failure are discussed. Recommendations are outlined for the use of digoxin in patients with renal failure aimed at circumventing the problem raised by a lowered apparent volume of distribution of the drug.
现报告 3 例肾功能衰竭伴地高辛表观分布容积降低的病例。其中 2 例出现明显地高辛中毒，1 例中毒表现不典型。3 例患者的地高辛血药浓度均大于 2ng/ml。讨论了肾功能衰竭时地高辛异常分布的可能原因。并对地高辛在肾功能衰竭患者中的应用提出了建议，旨在解决药物表观分布容积降低带来的问题。
