Civatte J, Moulonguet-Michau I, Marinho E, Cavelier-Balloy B, Verola O
Service de Dermatologie, Hôpital Saint-Louis, Paris.
Ann Dermatol Venereol. 1990;117(6-7):441-4.
We report three cases of epithelio-lympho-histiocytic tumour with very original histological features. The patients were young adults presenting with a nodular lesion on the face which had been present for several years. No recurrence was observed after surgical excision. Histologically, the dermal lesion consisted of epithelial pouches edged with a few layers of basal-like cells and filled with lymphocytes and large clear cells. Relations were found between these lobules and hair follicles, and rudiments of piliary differentiation were noted. The stroma was dense and infiltrated by small lymphocytes and large clear cells. An immunohistochemical study showed marking of the large clear cells by the S 100 protein, which suggested that they were Langerhans cells. The lymphocytes were recognized by the common panleucocyte antibody. The KL 1 antibody marked a few isolated cells within the lobules, but not the basal-like cells. These cases seemed to be similar to the 7 cases reported in the literature by Santa-Cruz and Barr who used the term lymphoepithelial tumour of the skin. We felt justified in putting the stress on the histiocytic component of this tumour and calling it epithelio-lympho-histiocytic tumour. We agree with these authors that this is a tumour of the appendages of the skin and in particular the hair.
我们报告了三例具有非常独特组织学特征的上皮-淋巴-组织细胞肿瘤。患者为年轻成年人，面部出现结节性病变，已存在数年。手术切除后未观察到复发。组织学上，真皮病变由上皮小囊组成，其边缘有几层基底样细胞，囊内充满淋巴细胞和大的透明细胞。发现这些小叶与毛囊之间存在联系，并注意到有毛发分化的痕迹。间质致密，有小淋巴细胞和大透明细胞浸润。免疫组织化学研究显示大透明细胞被S100蛋白标记，提示它们是朗格汉斯细胞。淋巴细胞被通用的全白细胞抗体识别。KL 1抗体标记了小叶内一些孤立的细胞，但未标记基底样细胞。这些病例似乎与Santa-Cruz和Barr在文献中报道的7例病例相似，他们将其称为皮肤淋巴上皮瘤。我们认为强调该肿瘤的组织细胞成分并将其称为上皮-淋巴-组织细胞肿瘤是合理的。我们同意这些作者的观点，即这是一种皮肤附属器肿瘤，尤其是毛发肿瘤。
