Aloi F, Tomasini C, Pippione M
Department of Dermatology, University of Turin, Italy.
Am J Dermatopathol. 1993 Aug;15(4):353-7.
Two additional cases of cutaneous lymphadenoma (CL) are reported. The lesions presented as single nodules of many years' duration on the face. Histologically, the neoplasms consisted of irregularly shaped lobules immersed in a dense fibroblastic stroma involving the whole dermis and extending into the subcutaneous fat. Duct-like structures suggesting an eccrine differentiation were recognized. The lobules were composed of a rim of basaloid cells surrounding large epithelioid cells and lymphocytes. In some areas the basaloid lobules were only partly replaced by the inflammatory cells. Immunohistochemically, the intralobular inflammatory component was composed of a mixed B- and T-cell population and S-100-positive dendritic cells. The observation of these cases suggests that CL is not a distinct entity but may represent a basal cell carcinoma, possibly with pilar or eccrine differentiation, in which an immune host reaction pattern is exceedingly unusual.
报告了另外两例皮肤淋巴结瘤（CL）。病变表现为面部多年持续存在的单个结节。组织学上，肿瘤由不规则形状的小叶组成，小叶浸于致密的成纤维细胞基质中，累及整个真皮并延伸至皮下脂肪。可见提示小汗腺分化的导管样结构。小叶由围绕大上皮样细胞和淋巴细胞的一层基底样细胞组成。在一些区域，基底样小叶仅部分被炎症细胞取代。免疫组化显示，小叶内炎症成分由混合的B细胞和T细胞群体以及S-100阳性树突状细胞组成。对这些病例的观察表明，CL并非一个独特的实体，而可能代表一种基底细胞癌，可能伴有毛囊或小汗腺分化，其中免疫宿主反应模式极为罕见。
