Department of Medical Nutrition, Karolinska Institute, Huddinge University Hospital, Huddinge, Sweden.
J Steroid Biochem Mol Biol. 1992 Dec;43(8):1045-53. doi: 10.1016/0960-0760(92)90332-D.
The determination of sexually dimorphic hepatic steroid metabolism in rat liver has been shown to involve growth hormone. However, the mechanisms by which growth hormone controls the cytochrome P450 enzymes responsible for this dimorphic steroid metabolism is largely unknown. In this review we discuss different levels of growth hormone signal transduction, including receptor binding, signal transduction and activation of target genes by growth hormone.
已经证明，大鼠肝脏中性别二态性肝甾体代谢的确定涉及生长激素。然而，生长激素控制负责这种性别二态性甾体代谢的细胞色素 P450 酶的机制在很大程度上尚不清楚。在这篇综述中，我们讨论了生长激素信号转导的不同层次，包括受体结合、信号转导以及生长激素对靶基因的激活。
