Dell'Aquila Angelo Maria, Mastrobuoni Stefano, Bastarrika Gorka, Praschker Beltran Levy, Agüero Pedro Azcárate, Castaño Sara, Herreros Jesus, Rabago Gregorio
Department of Cardiovascular Surgery, Clinical University of Navarra, Pamplona, Spain.
Interact Cardiovasc Thorac Surg. 2012 Apr;14(4):457-62. doi: 10.1093/icvts/ivr084. Epub 2012 Jan 4.
Despite a more physiological morphology of atrial anastomosis in the bicaval technique with respect to standard biatrial anastomosis in orthotopic heart transplantation (OHT), the impact on the long-term outcome is still not clear. In this retrospective study, we sought to investigate the morphology and function of the atria through magnetic resonance imaging (MRI) and transthoracic echocardiography (TTE). Moreover, we aimed to analyse the accuracy of TTE with respect to MRI. Cox regression analysis of 216 consecutive patients receiving OHT between August 1987 and January 2010 identified only recipient age at the time of transplant to be an independent predictor of mortality (P = 0.048, odds ratio = 1.04). After a mean follow-up of 96.6 ± 77.7 months, 108 patients were alive, of which 35 were found to be eligible for MRI assessment. In this analysis, left and right atrial volumes were found to be significantly larger in the standard group in comparison with the bicaval group (P = 0.001), and no significant difference between the two techniques was observed in left and right atrio-ventricular output. Moreover, a significantly reduced accuracy was observed (CCC < 0.3) when TTE results were compared with MRI assessment in evaluating atrial dimensions. Although left and right atrial volumes are significantly larger in the standard group in comparison with the bicaval group, we concluded that no significant difference in the atrial output and survival between the two techniques could be demonstrated.
尽管在原位心脏移植(OHT)中,双腔静脉技术的心房吻合术相对于标准双心房吻合术具有更符合生理的形态,但对长期预后的影响仍不明确。在这项回顾性研究中,我们试图通过磁共振成像(MRI)和经胸超声心动图(TTE)来研究心房的形态和功能。此外,我们旨在分析TTE相对于MRI的准确性。对1987年8月至2010年1月期间连续接受OHT的216例患者进行的Cox回归分析表明,仅移植时的受者年龄是死亡率的独立预测因素(P = 0.048,比值比 = 1.04)。在平均随访96.6±77.7个月后,108例患者存活,其中35例被认为符合MRI评估条件。在该分析中,发现标准组的左、右心房容积明显大于双腔静脉组(P = 0.001),并且在左、右房室输出量方面未观察到两种技术之间存在显著差异。此外,在评估心房大小时,将TTE结果与MRI评估进行比较时,观察到准确性显著降低(CCC < 0.3)。尽管标准组的左、右心房容积明显大于双腔静脉组,但我们得出结论,两种技术在心房输出量和生存率方面无显著差异。