Domloge-Hultsch N, Utecht L, James W, Yancey K B
Department of Dermatology, Uniformed Services University of the Health Sciences, Bethesda, Md 20814-4799.
Arch Dermatol. 1990 Oct;126(10):1337-41.
Two patients demonstrating the typical clinical, histologic, and immunopathologic features of nonscarring localized bullous pemphigoid are described. These patients possess circulating IgG autoantibodies that bind the epidermal side of 1.0-mol/L sodium chloride-split human skin in indirect immunofluorescence microscopy. Immunnoprecipitation studies demonstrate that these patients have circulating autoantibodies that immunoprecipitate the same 230-kd bullous pemphigoid antigen that is precipitated by autoantibodies from patients with generalized bullous pemphigoid. These findings indicate that localized bullous pemphigoid is a true clinical variant of generalized pemphigoid rather than a separate nosologic entity.
本文描述了两名表现出非瘢痕性局限性大疱性类天疱疮典型临床、组织学和免疫病理学特征的患者。在间接免疫荧光显微镜检查中，这些患者的循环IgG自身抗体可与1.0摩尔/升氯化钠分离的人皮肤表皮侧结合。免疫沉淀研究表明，这些患者的循环自身抗体可免疫沉淀与泛发性大疱性类天疱疮患者的自身抗体沉淀出的相同的230-kd大疱性类天疱疮抗原。这些发现表明，局限性大疱性类天疱疮是泛发性类天疱疮的一种真正临床变体，而非一个独立的病种。
