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Blastic plasmacytoid dendritic cell neoplasm on the scalp.

作者信息

Fukushi Sawako, Taku Fujimura, Aiba Setsuya

机构信息

Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.

出版信息

Case Rep Dermatol. 2011 Sep;3(3):240-3. doi: 10.1159/000334927. Epub 2011 Nov 29.

DOI:10.1159/000334927
PMID:22220144
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3250667/
Abstract

We describe a 75-year-old Japanese woman with blastic plasmacytoid dendritic cell neoplasm. On her first visit, there were multiple areas of disseminated, elastic hard nodules with multicentric purpura on her scalp. Histopathologically, there were atypical large lymphocytes densely infiltrated through the upper dermis to subcutaneous tissue. Immunohistochemical staining revealed that these infiltrated lymphocytes were CD4, CD56 and vimentin positive. Although we administered several courses of intensive chemotherapy soon after the diagnosis, the patient died 5 months after the first visit.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e911/3250667/cc63541cbe9a/cde0003-0240-f02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e911/3250667/7214a7851405/cde0003-0240-f01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e911/3250667/cc63541cbe9a/cde0003-0240-f02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e911/3250667/7214a7851405/cde0003-0240-f01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e911/3250667/cc63541cbe9a/cde0003-0240-f02.jpg

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本文引用的文献

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A case of blastic plasmacytoid dendritic cell neoplasm initially mimicking cutaneous lupus erythematosus.一例起初类似皮肤红斑狼疮的原始浆细胞样树突细胞肿瘤。
Cancer Res Treat. 2010 Dec;42(4):239-43. doi: 10.4143/crt.2010.42.4.239. Epub 2010 Dec 31.
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A case of cutaneous blastic plasmacytoid dendritic cell neoplasm.一例皮肤原始浆细胞样树突状细胞肿瘤。
Acta Derm Venereol. 2010 Nov;90(6):645-6. doi: 10.2340/00015555-0922.
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Blastic plasmacytoid dendritic cell neoplasm.母细胞性浆细胞样树突状细胞肿瘤
J Clin Oncol. 2011 Jan 10;29(2):e27-9. doi: 10.1200/JCO.2010.30.5441. Epub 2010 Oct 12.
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Cutaneous CD4+ CD56+ hematologic malignancies.皮肤 CD4+ CD56+ 血液恶性肿瘤。
J Am Acad Dermatol. 2010 Aug;63(2):292-308. doi: 10.1016/j.jaad.2009.08.044. Epub 2010 Jun 11.
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Blastic NK-cell lymphomas (agranular CD4+CD56+ hematodermic neoplasms): a review.母细胞性NK细胞淋巴瘤（无颗粒CD4+CD56+血液肿瘤）：综述
Am J Clin Pathol. 2005 May;123(5):662-75.
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CD4+ CD56+ blastic tumor of the skin: cytogenetic observations and further evidence of an origin from plasmocytoid dendritic cells.皮肤CD4+ CD56+母细胞性肿瘤：细胞遗传学观察及源自浆细胞样树突状细胞的进一步证据
Eur J Dermatol. 2004 Sep-Oct;14(5):317-22.
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TCL1 and CLA expression in agranular CD4/CD56 hematodermic neoplasms (blastic NK-cell lymphomas) and leukemia cutis.TCL1和CLA在无颗粒CD4/CD56皮肤血液肿瘤（母细胞性NK细胞淋巴瘤）及皮肤白血病中的表达。
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