School of Psychological Science, La Trobe University, Melbourne, Victoria 3086, Australia.
J Clin Exp Neuropsychol. 2012;34(3):269-78. doi: 10.1080/13803395.2011.633498. Epub 2012 Jan 6.
Amnestic mild cognitive impairment (aMCI) delineates a population at high risk for subsequently developing Alzheimer's disease (AD)--that is, people with preclinical AD. Associative episodic memory tasks are particularly sensitive to preclinical AD; however, they often lack ecological validity, which is important when evaluating performance in daily activities. We describe the development of two quasi-everyday associative memory tasks--the La Trobe Face-Name test and the La Trobe Numberplate task--and their utility in profiling and separating 70 aMCI participants from 101 healthy older adults (HOA) compared with standard episodic memory tasks. aMCI participants performed significantly worse overall and demonstrated a greater forgetting rate than HOA on both tasks. The everyday tasks separated aMCI from HOA participants as effectively as standard episodic memory tasks and were well tolerated. These tasks provide a valuable addition to neuropsychologists' toolkits with enhanced ecological (verisimilitude) and face validity for assisting in counseling clients, measuring the effect of interventions, and profiling everyday memory performance in HOA and aMCI.
遗忘型轻度认知障碍 (aMCI) 将处于高风险状态,随后发展为阿尔茨海默病 (AD) 的人群进行了划分——即有临床前 AD 的人群。联想性情景记忆任务对临床前 AD 特别敏感;然而,它们往往缺乏生态有效性,这在评估日常活动中的表现时非常重要。我们描述了两种准日常联想记忆任务——拉筹伯面孔-姓名测试和拉筹伯车牌任务的开发,以及它们在与标准情景记忆任务相比,对 70 名 aMCI 参与者和 101 名健康老年人 (HOA) 进行分析和区分的效用。aMCI 参与者在这两项任务中的整体表现明显更差,且与 HOA 相比,他们的遗忘率更高。日常任务能够像标准情景记忆任务一样有效地将 aMCI 与 HOA 参与者区分开来,并且耐受性良好。这些任务为神经心理学家的工具包提供了有价值的补充,增强了生态(逼真度)和表象有效性,有助于为客户提供咨询,衡量干预措施的效果,以及分析 HOA 和 aMCI 的日常记忆表现。