Mak Michael C H, Cheing Gladys L Y
Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR, China.
Photomed Laser Surg. 2012 Apr;30(4):193-9. doi: 10.1089/pho.2011.3012. Epub 2012 Jan 5.
The purpose of this study was to evaluate the influence of monochromatic infrared energy (MIRE) on the microcirculation of the skin surface of the feet in healthy subjects.
Near-infrared energy was shown to increase microcirculation in an animal study. In humans, only one case study demonstrated that MIRE increases microcirculation in the skin of the lower limbs.
Thirty healthy volunteers were recruited and randomly allocated into three groups to receive either: (1) active MIRE; (2) sham MIRE (placebo group); or (3) warm packs (control group) on the feet. The MIRE device comprised an array of 60 x 890 nm LEDs attached to flexible pads (3×7.5 cm). Each diode spot size was 0.2 cm(2), and each LED power was 12 mW with a power density of 60 mW/cm(2). The arrays were placed in direct contact with the skin for 30 min delivering a total fluence of 108 J/cm(2) over an area of 22.5 cm(2). Capillary blood cell velocity (CBV) and superficial skin blood flow (flux) were recorded before and after intervention.
Significant differences among the three groups were recorded in both CBV and flux (both p<0.05). Post-hoc comparisons indicated that a significantly greater increase in both CBV and flux occurred in the active MIRE group than in the placebo group and control group (all p<0.05).
A 30-min MIRE produced a significantly greater increase in the CBV and flux of the feet in the active MIRE group than in the placebo and control groups.
本研究旨在评估单色红外能量（MIRE）对健康受试者足部皮肤表面微循环的影响。
在一项动物研究中，近红外能量被证明可增加微循环。在人类中，仅有一项病例研究表明MIRE可增加下肢皮肤的微循环。
招募30名健康志愿者，随机分为三组，分别接受以下处理：（1）主动MIRE；（2）假MIRE（安慰剂组）；或（3）足部热敷（对照组）。MIRE装置由附着在柔性垫（3×7.5 cm）上的60个890 nm发光二极管阵列组成。每个二极管光斑尺寸为0.2 cm²，每个发光二极管功率为12 mW，功率密度为60 mW/cm²。将阵列直接与皮肤接触30分钟，在22.5 cm²的面积上传递的总能量通量为108 J/cm²。在干预前后记录毛细血管血细胞速度（CBV）和浅表皮肤血流（通量）。
三组在CBV和通量方面均有显著差异（均p<0.05）。事后比较表明，主动MIRE组的CBV和通量增加幅度显著大于安慰剂组和对照组（均p<0.05）。
与安慰剂组和对照组相比，主动MIRE组中30分钟的MIRE使足部的CBV和通量显著增加。
