Cardiovascular and Thoracic Section, Department of Anesthesiology and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
J Cardiothorac Vasc Anesth. 2012 Feb;26(1):3-10. doi: 10.1053/j.jvca.2011.10.005.
There have been rapid advances in oral anticoagulation. The oral factor Xa inhibitors rivaroxaban and apixaban and the oral direct thrombin inhibitor dabigatran recently have been rigorously evaluated. These novel anticoagulants will usher in a new paradigm for perioperative anticoagulation. Perioperative blood conservation in cardiac surgery recently has been highlighted in the updated guidelines by the Society of Cardiovascular Anesthesiologists and the Society of Thoracic Surgeons. These recommendations reflect a comprehensive evaluation of the recent evidence to optimize transfusion practice. Transcatheter mitral valve repair continues to mature. Transcatheter aortic valve implantation for aortic stenosis has entered the clinical mainstream, with randomized trials showing its superiority over medical management and its equivalency to surgical valve replacement in high-risk patients. This transformational technology represents a major leadership opportunity for the cardiac anesthesiologist. Minimally invasive valve surgery has shown effectiveness in high-risk patients. Radial access is equivalent to femoral access for percutaneous coronary intervention in acute coronary syndromes but significantly reduces the risk of local vascular complications. Recent trials have further clarified the roles of medical therapy, percutaneous coronary intervention, and coronary artery bypass surgery in patients with significant coronary artery disease and left ventricular dysfunction. The past year has witnessed major advances in cardiovascular practice with new drugs, new devices, and new guidelines. The coming year most likely will advance these achievements to enhance the care of patients.
在口服抗凝领域取得了快速进展。新型口服抗凝药物如利伐沙班、阿哌沙班和达比加群已得到严格评估。这些新型抗凝药物将为围手术期抗凝带来新的范式。心血管麻醉师协会和胸外科医师协会的更新指南最近强调了心脏手术中的围手术期血液保护。这些建议反映了对近期证据的全面评估,以优化输血实践。经导管二尖瓣修复术继续成熟。经导管主动脉瓣植入术治疗主动脉瓣狭窄已进入临床主流,随机试验表明其优于药物治疗,在高危患者中与外科瓣膜置换术等效。这项变革性技术为心脏麻醉师提供了重大领导机会。微创瓣膜手术在高危患者中显示出有效性。桡动脉入路与股动脉入路在急性冠状动脉综合征的经皮冠状动脉介入治疗中等效,但显著降低了局部血管并发症的风险。最近的试验进一步阐明了在有严重冠状动脉疾病和左心室功能障碍的患者中药物治疗、经皮冠状动脉介入治疗和冠状动脉旁路手术的作用。过去一年见证了心血管实践的重大进展,包括新药、新设备和新指南。未来一年很可能会推进这些成就,以改善患者的治疗效果。