Ishii A, Ito K, Yamashita N, Miyamoto T, Shiga J, Watanabe N
Department of Medicine, Faculty of Medicine, University of Tokyo.
Arerugi. 1990 Jun;39(6):502-8.
We established an experimental animal model for IgE-mediated asthma by the use of intravenous injection of rabbit anti guinea pig IgE in normal guinea pigs. The degree of asthmatic airway obstruction was quantitatively estimated by Mead's apparatus which enabled us to use unanesthetized guinea pigs. With the injection of anti IgE, only an early asthmatic response was observed. Inhalation of anti IgE did not trigger asthma. Histo-pathological changes in the lung obtained immediately after the injection of anti IgE resembled those reported in human asthma. This system may be used for pathological and pharmacological studies of the IgE-dependent early asthmatic response.
我们通过向正常豚鼠静脉注射兔抗豚鼠IgE建立了IgE介导的哮喘实验动物模型。使用米德装置对哮喘气道阻塞程度进行定量评估，该装置使我们能够使用未麻醉的豚鼠。注射抗IgE后，仅观察到早期哮喘反应。吸入抗IgE不会引发哮喘。注射抗IgE后立即获取的肺组织病理变化与人类哮喘中报道的相似。该系统可用于IgE依赖性早期哮喘反应的病理和药理学研究。
