Heart Failure Center, Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital, Keelung, Taoyuan, Taiwan.
J Investig Med. 2012 Feb;60(2):523-8. doi: 10.2310/JIM.0b013e3182408549.
A recent study showed that periostin (PN) induced reentry of differentiated cardiomyocytes into the cell cycle and improved heart function after acute myocardial infarction (AMI). This study sought to investigate whether PN levels increase after AMI and whether they provide prognostic value.
We recruited 123 patients: 45 with AMI, 45 with stable coronary artery disease (CAD), and 33 healthy controls (CON). Blood PN and N-terminal pro-brain natriuretic peptide (NT-pro-BNP) levels were measured. Echocardiography was repeated 3 months after AMI. In the AMI group, the PN levels 1.3 ± 1.2 days after AMI were significantly lower than those in the CAD and CON groups (175 ± 60, 245 ± 68, and 232 ± 63 ng/mL, respectively, P = 0.001). The NT-pro-BNP levels were significantly higher in the AMI group, compared to the CON and CAD groups (10.07 ± 28.2 [median, 0.70] vs 0.08 ± 0.06 [median, 0.05] and 1.1 ± 4.2 [median, 0.09] ng/mL, respectively; P = 0.02). The PN levels further decreased 8 ± 2 days after AMI (from 175 ± 60 to 143 ± 57 ng/mL; P = 0.003). However, NT-pro-BNP levels did not significantly change. With respect to the echocardiographic parameters 3 months after AMI, the PN levels measured before discharge were negatively associated with the left ventricular ejection fraction (rs = -0.50; P = 0.001), end diastolic (rs = 0.42; P = 0.009) and systolic (rs = 0.46; P = 0.004) diameters. The NT-pro-BNP levels were not significantly correlated with these parameters.
Acute myocardial infarction is associated with a decrease in blood PN levels, and PN concentrations predict cardiac function 3 months after AMI.
最近的一项研究表明，骨膜蛋白（PN）可诱导分化的心肌细胞重新进入细胞周期，并改善急性心肌梗死（AMI）后的心脏功能。本研究旨在探讨 AMI 后 PN 水平是否升高，以及它们是否具有预后价值。
我们招募了 123 名患者：45 名 AMI 患者、45 名稳定型冠状动脉疾病（CAD）患者和 33 名健康对照者（CON）。测量血液 PN 和 N 末端脑钠肽前体（NT-pro-BNP）水平。AMI 后 3 个月重复进行超声心动图检查。在 AMI 组中，AMI 后 1.3±1.2 天的 PN 水平明显低于 CAD 组和 CON 组（分别为 175±60、245±68 和 232±63ng/mL，P=0.001）。与 CON 和 CAD 组相比，AMI 组的 NT-pro-BNP 水平明显升高（10.07±28.2[中位数，0.70]vs0.08±0.06[中位数，0.05]和 1.1±4.2[中位数，0.09]ng/mL，P=0.02）。AMI 后 8±2 天，PN 水平进一步下降（从 175±60 降至 143±57ng/mL；P=0.003）。然而，NT-pro-BNP 水平没有明显变化。对于 AMI 后 3 个月的超声心动图参数，出院前测量的 PN 水平与左心室射血分数呈负相关（rs=-0.50；P=0.001），与舒张末期（rs=0.42；P=0.009）和收缩末期（rs=0.46；P=0.004）直径呈负相关。NT-pro-BNP 水平与这些参数无显著相关性。
急性心肌梗死后血液 PN 水平下降，PN 浓度可预测 AMI 后 3 个月的心脏功能。
