Williams D F, Peters M A, Abrams G W, Han D P, Mieler W F
Department of Ophthalmology, Medical College of Wisconsin, Milwaukee.
Arch Ophthalmol. 1990 Oct;108(10):1484-6. doi: 10.1001/archopht.1990.01070120132043.
We describe herein a two-stage technique of intraoperative fluid-gas exchange following pars plana vitrectomy. The first stage is a complete fluid-air exchange using an air pump and intraocular linear suction. The air pump then maintains the intraocular pressure at the desired level during adjunctive procedures, such as laser endophotocoagulation. The second stage is an air-gas mixture exchange in which the desired gas, premixed in air to the desired final intraocular concentration, is manually flushed through the eye. This technique allows the attainment of an accurate concentration of intraocular gas if the air-gas mixture exchange is complete. In vitro and in vivo experiments in aphakic human eyes demonstrated that an effectively complete air-gas mixture exchange occurs with a 25-mL flush volume. This result compares favorably with the theoretical prediction derived from a "pharmacokinetic approximation" equation.
我们在此描述一种玻璃体切割术后术中液体 - 气体交换的两阶段技术。第一阶段是使用气泵和眼内线性抽吸进行完全的液体 - 空气交换。然后气泵在辅助操作（如激光眼内光凝）期间将眼内压维持在所需水平。第二阶段是空气 - 气体混合物交换，其中预先与空气混合至所需最终眼内浓度的所需气体通过眼睛手动冲洗。如果空气 - 气体混合物交换完成，该技术可实现眼内气体的准确浓度。无晶状体人眼的体外和体内实验表明，25毫升冲洗量可实现有效的完全空气 - 气体混合物交换。该结果与从“药代动力学近似”方程得出的理论预测相比具有优势。
