Department of Community Health Sciences, University of Calgary, Calgary, AB, Canada.
Rheumatology (Oxford). 2012 May;51(5):878-81. doi: 10.1093/rheumatology/ker418. Epub 2012 Jan 5.
To compare the ability of the simple erosion narrowing score (SENS) to classify radiographic progression relative to the Sharp/van der Heijde score (SHS) in a prospective cohort of anti-TNF-treated RA patients.
Radiographs of the hands, wrists and feet of patients enrolled in a pharmacovigilance programme are performed every 2 years. These radiographs were read in chronological order by three rheumatologists and scored using the SHS. SENS scores were derived from the SHS. Additionally, one rheumatologist scored the radiographs using the SENS method only. Patients with radiographic progression in excess of the smallest detectable change were classified as progressors. The probability of agreement and κ-value between the SHS and SENS methods for determining progression was calculated.
A sample of 25 patients was selected from the database. The annualized mean (s.d.) change in SHS score was 6.61 U (7.48 U) and in SENS score was 2.27 U (2.17 U). Five patients were classified as progressors using SHS and seven using SENS, with a probability of agreement of 84% (κ = 0.565).
The SENS method captures radiographic progression reliably compared with the more detailed SHS method. SENS is suitable for application in clinical practice or in observational cohorts.
比较简单侵蚀狭窄评分（SENS）与 Sharp/van der Heijde 评分（SHS）在接受抗 TNF 治疗的 RA 患者前瞻性队列中对放射学进展的分类能力。
纳入药物监测计划的患者的手部、腕部和足部的 X 光片每两年拍摄一次。这些 X 光片由三位风湿病学家按时间顺序阅读，并使用 SHS 进行评分。SENS 评分来自 SHS。此外，一位风湿病学家仅使用 SENS 方法对 X 光片进行评分。放射学进展超过最小可检测变化的患者被归类为进展者。计算 SHS 和 SENS 方法确定进展的一致性概率和κ 值。
从数据库中选择了 25 名患者的样本。SHS 评分的年化平均（s.d.）变化为 6.61 U（7.48 U），SENS 评分的年化平均（s.d.）变化为 2.27 U（2.17 U）。5 名患者使用 SHS 被归类为进展者，7 名患者使用 SENS 被归类为进展者，一致性概率为 84%（κ=0.565）。
与更详细的 SHS 方法相比，SENS 方法可靠地捕捉放射学进展。SENS 适用于临床实践或观察性队列。
