经阴道使用前列腺素E2引产在多产妇中的安全性。
Safety of induction of labor with vaginal prostaglandins (e2) in grandmultipara.
作者信息
Paliwal Veena, Dikhit Sushma, Singh Sonal
出版信息
Oman Med J. 2009 Jul;24(3):184-7. doi: 10.5001/omj.2009.36.
OBJECTIVES
The aim of this study is to determine safety of induction of labor with vaginal Prostaglandins (E2) in Grand Multipara.
METHODS
Prostaglandin E2 was used in the form of vaginal tablets or gel in post fornix for induction as per protocol. Maternal and fetal data collected included age, parity, and indication of induction, bishops score, total dose of PGE2 used & complications of induction of labor. The data was collected and analyzed using Epi info - 6.
RESULTS
50% cases were induced for past dates, the ceasarean rate was high in the induction group (19.5%) compared to the control (12.5%) OR 1.69 RR 1.37(95% CI-1.07-1.75) difference was statistically significant. Adverse neonatal outcome was found to be similar in both groups. Special Care Baby Unit (SCBU) admissions were 19 in the induction group and 21 in the control group, which was not statistically significant. No severe maternal complications were observed such as infection or uterine rupture.
CONCLUSION
As there were no adverse events in the study, it may be safe to use vaginal PGE2 as method of choice for induction of labour in grand mutipara. However, RCT for further validation of these findings is recommended.
目的
本研究旨在确定经阴道使用前列腺素（E2）引产在多产妇中的安全性。
方法
按照方案，将前列腺素E2以阴道片或凝胶的形式置于后穹窿用于引产。收集的母胎数据包括年龄、产次、引产指征、 Bishop评分、使用的PGE2总剂量及引产并发症。使用Epi info - 6收集并分析数据。
结果
50%的病例因过期妊娠引产，引产组的剖宫产率（19.5%）高于对照组（12.5%），比值比为1.69，相对危险度为1.37（95%可信区间为1.07 - 1.75），差异有统计学意义。两组的不良新生儿结局相似。引产组有19例入住特殊护理婴儿病房（SCBU），对照组有21例，差异无统计学意义。未观察到严重的母体并发症，如感染或子宫破裂。
结论
由于本研究中未出现不良事件，在多产妇中使用阴道PGE2作为引产的首选方法可能是安全的。然而，建议进行随机对照试验以进一步验证这些结果。
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