Tulloch-Reid M K, Aiken W D, Morrison B F, Tulloch T, Mayhew R, Wan R L, Bennett F I, Coard K C, Jackson M D
Epidemiology Research Unit, TMRI, The University of the West Indies.
West Indian Med J. 2011 Jun;60(3):316-21.
To investigate the relationship between body mass index (BMI) and prostate specific antigen (PSA) levels in Jamaican men.
Men, 40-79 years old, attending public and private urology clinics in Kingston, Jamaica were recruited to a case-control study on the role of dietary and lifestyle factors on prostate cancer. Trained interviewers administered questionnaires and measured weight and height using standardized techniques. Blood samples for PSA were measured at a central laboratory using a micro-particle enzyme immunoassay method. Prostate biopsy was used to confirm prostate cancer. Multivariable linear regression was used to examine the relationship between BMI and PSA separately in the cases and controls.
Data from 501 men (233 cases and 263 controls) were assessed. Thirty-five per cent of subjects were overweight and 13% were obese. Among cases, the median PSA was 35.3 ng/dL in normal weight, 26.1 ng/dL in overweight and 14.5 ng/dL in obese men (p = 0.02). For controls, median PSA was 2.0 ng/dL in normal weight, 1.3 ng/dL in overweight and 1.1ng/dl in obese men (p = 0.01). Among cases, BMI was negatively associated with PSA (B(SE) per 5 kg/m2 (BMI difference = -0.51 (0.13); p < 0.01) and remained significant after adjustment for age, sexual activity, smoking, use of statins and tumour grade. For controls, the BMI was also inversely related to the PSA (B(SE) per 5 kg/m2 difference -0.17 (0.07)) but the effect became of borderline significance after adjusting for age.
Prostate specific antigen was inversely related to body mass index in Jamaican men with prostate cancer. Clinicians should consider this association when interpreting PSA results.
研究牙买加男性体重指数（BMI）与前列腺特异性抗原（PSA）水平之间的关系。
招募年龄在40 - 79岁、在牙买加金斯敦公立和私立泌尿外科诊所就诊的男性参与一项关于饮食和生活方式因素对前列腺癌作用的病例对照研究。训练有素的访员发放问卷，并使用标准化技术测量体重和身高。在中央实验室采用微粒子酶免疫测定法检测PSA血样。通过前列腺活检确诊前列腺癌。采用多变量线性回归分别在病例组和对照组中研究BMI与PSA之间的关系。
对501名男性（233例病例和263例对照）的数据进行了评估。35%的受试者超重，13%的受试者肥胖。在病例组中，正常体重男性的PSA中位数为35.3 ng/dL，超重男性为26.1 ng/dL，肥胖男性为14.5 ng/dL（p = 0.02）。对于对照组，正常体重男性的PSA中位数为2.0 ng/dL，超重男性为1.3 ng/dL，肥胖男性为1.1 ng/dL（p = 0.01）。在病例组中，BMI与PSA呈负相关（每5 kg/m²的B(SE)（BMI差异 = -0.51(0.13)；p < 0.01），在调整年龄、性活动、吸烟、他汀类药物使用和肿瘤分级后仍具有显著性。对于对照组，BMI也与PSA呈负相关（每5 kg/m²差异的B(SE) -0.17(0.07)），但在调整年龄后，该效应接近显著水平。
在患有前列腺癌的牙买加男性中，前列腺特异性抗原与体重指数呈负相关。临床医生在解读PSA结果时应考虑这种关联。
