注意：阱式离子迁移谱与质谱联用。
Note: Integration of trapped ion mobility spectrometry with mass spectrometry.
作者信息
Fernandez-Lima F A, Kaplan D A, Park M A
机构信息
Department of Chemistry, Texas A&M University, College Station, Texas 77843-3144, USA.
出版信息
Rev Sci Instrum. 2011 Dec;82(12):126106. doi: 10.1063/1.3665933.
Abstract
The integration of a trapped ion mobility spectrometer (TIMS) with a mass spectrometer (MS) for complementary fast, gas-phase mobility separation prior to mass analysis (TIMS-MS) is described. The ion transmission and mobility separation are discussed as a function of the ion source condition, bath gas velocity, analysis scan speed, RF ion confinement, and downstream ion optical conditions. TIMS mobility resolution depends on the analysis scan speed and the bath gas velocity, with the unique advantage that the IMS separation can be easily tuned from high speed (~25 ms) for rapid analysis to slower scans for higher mobility resolution (R > 80).
摘要
本文描述了将捕集离子淌度谱仪（TIMS）与质谱仪（MS）集成，用于在质量分析之前进行互补的快速气相淌度分离（TIMS-MS）。讨论了离子传输和淌度分离与离子源条件、缓冲气体流速、分析扫描速度、射频离子限制以及下游离子光学条件的关系。TIMS淌度分辨率取决于分析扫描速度和缓冲气体流速，其独特优势在于离子淌度谱分离可以很容易地从用于快速分析的高速（约25毫秒）调整到用于更高淌度分辨率（R>80）的较慢扫描。
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本文引用的文献
1
Gas-phase separation using a trapped ion mobility spectrometer.使用捕获离子迁移谱仪进行气相分离。
Int J Ion Mobil Spectrom. 2011 Sep;14(2-3). doi: 10.1007/s12127-011-0067-8.
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