小狗体外循环下重度肺动脉狭窄的外科治疗
Surgical treatment of severe pulmonic stenosis under cardiopulmonary bypass in small dogs.
作者信息
Fujiwara M, Harada K, Mizuno T, Nishida M, Mizukoshi T, Mizuno M, Uechi M
机构信息
Department of Veterinary Internal Medicine, Nihon University, 1866 Kameino, Fujisawa, Kanagawa, Japan.
出版信息
J Small Anim Pract. 2012 Feb;53(2):89-94. doi: 10.1111/j.1748-5827.2011.01163.x. Epub 2012 Jan 9.
OBJECTIVES
The aim of this study was to report the long-term outcome of the surgical palliation of pulmonic stenosis in dogs.
METHODS
The subjects comprised three female and six male dogs, mean (±sd) age: 23 (±25) months, mean (±sd) weight: 3·4 (±2·1) kg, diagnosed with severe pulmonic stenosis and right ventricular hypertrophy, with an average preoperative pressure gradient of 153 (±43) mmHg on echocardiography.
RESULTS
The pressure overload with severe pulmonic stenosis was reduced by valvotomy, i.e., open pulmonary valve commissurotomy, with/without biomembrane patch grafting, under cardiopulmonary bypass. The postoperative pressure gradient at 1 to 7 days was significantly decreased to 65 (±39) mmHg (P<0·05). The reduced pressure gradient was maintained at 58 (±38) mmHg at final follow-up.
CLINICAL SIGNIFICANCE
Open valvotomy, pulmonary valve commissurotomy and biomembrane patch grafting were effective in reducing obstruction in severe pulmonic stenosis in dogs.
目的
本研究旨在报告犬肺动脉狭窄手术姑息治疗的长期结果。
方法
研究对象包括3只雌性犬和6只雄性犬，平均（±标准差）年龄：23（±25）个月，平均（±标准差）体重：3.4（±2.1）kg，诊断为重度肺动脉狭窄和右心室肥厚，术前超声心动图平均压力阶差为153（±43）mmHg。
结果
在体外循环下，通过瓣膜切开术，即开放肺动脉瓣交界切开术，伴或不伴生物膜补片移植，减轻了重度肺动脉狭窄引起的压力负荷。术后1至7天的压力阶差显著降至65（±39）mmHg（P<0.05）。在最后随访时，降低的压力阶差维持在58（±38）mmHg。
临床意义
开放瓣膜切开术、肺动脉瓣交界切开术和生物膜补片移植对减轻犬重度肺动脉狭窄的梗阻有效。
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