Khaddar R Kort, Mahjoub W Koubaa, Zaraa I, Sassi M Ben, Osman A Ben, Debbiche A Chadli, Mokni M
Service de dermatologie, EPS La Rabta, Jabbari, Tunis, Tunisie.
Ann Dermatol Venereol. 2012 Jan;139(1):54-7. doi: 10.1016/j.annder.2011.10.403. Epub 2011 Dec 6.
Dowling-Degos disease is a rare and benign inherited dermatosis.
A 53-year-old woman presented with generalized histologically confirmed Dowling-Degos disease revealed 8 years after psoralen photochemotherapy (PUVA) for psoriasis. This presentation was special in terms of its considerable spread as well as the absence of comedone-like and punctate scars.
Dowling-Degos disease is a reticulate pigmentary disorder of the flexures associating prominent comedone-like lesions and pitted scars. Diagnosis is based on clinical and histopathological examination, which allows this entity to be differentiated from other reticulate pigmentary disorders. A literature review failed to provide any indication that PUVA therapy either aggravates or reveals Dowling-Degos disease, a finding which we feel merits mention.
Dowling-Degos病是一种罕见的良性遗传性皮肤病。
一名53岁女性，在接受补骨脂素光化学疗法（PUVA）治疗银屑病8年后，出现经组织学确诊的泛发性Dowling-Degos病。该病例表现特殊，病变广泛，且无类似粉刺样和点状瘢痕。
Dowling-Degos病是一种发生于褶皱部位的网状色素沉着性疾病，伴有明显的类似粉刺样损害和凹陷性瘢痕。诊断基于临床和组织病理学检查，借此可将该病与其他网状色素沉着性疾病相鉴别。文献回顾未发现任何证据表明PUVA治疗会加重或引发Dowling-Degos病，我们认为这一发现值得一提。
