铁螯合作用对过氧化氢诱导的H9C2细胞损伤具有心脏保护作用：新型3-羟基吡啶-4-酮衍生物的应用。 - Suppr

Iron chelation afforded cardioprotection against H2O2-induced H9C2 cell injury: application of novel 3-hydroxy pyridine-4-one derivatives.

作者信息

Sabet Razieh, Behjati Mohaddeseh, Vahabpour Rouhollah, Memarnejadian Arash, Rostami Mahboubeh, Fassihi Afshin, Aghasadeghi Mohammad R, Saghaie Lotfollah, Miri Ramin

出版信息

Int J Cardiol. 2012 Dec 15;162(1):60-3. doi: 10.1016/j.ijcard.2011.11.067. Epub 2012 Jan 9.

DOI:10.1016/j.ijcard.2011.11.067

PMID:22225757

Abstract

摘要

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Iron chelation afforded cardioprotection against H2O2-induced H9C2 cell injury: application of novel 3-hydroxy pyridine-4-one derivatives.铁螯合作用对过氧化氢诱导的H9C2细胞损伤具有心脏保护作用：新型3-羟基吡啶-4-酮衍生物的应用。

Int J Cardiol. 2012 Dec 15;162(1):60-3. doi: 10.1016/j.ijcard.2011.11.067. Epub 2012 Jan 9.

SIH--a novel lipophilic iron chelator--protects H9c2 cardiomyoblasts from oxidative stress-induced mitochondrial injury and cell death.新型亲脂性铁螯合剂SIH可保护H9c2心肌母细胞免受氧化应激诱导的线粒体损伤和细胞死亡。

J Mol Cell Cardiol. 2005 Aug;39(2):345-54. doi: 10.1016/j.yjmcc.2005.05.008.

Oral iron chelation.口服铁螯合疗法。

Semin Hematol. 1996 Jan;33(1):1-8.

Prospects for effective oral iron chelation therapy in man with 1,2-dimethyl-3-hydroxypyrid-4-one and other alpha-ketohydroxypyridines.1,2 - 二甲基 - 3 - 羟基吡啶 - 4 - 酮及其他α - 酮羟基吡啶用于人体有效口服铁螯合疗法的前景

Prog Clin Biol Res. 1989;309:107-14.

Prospects for oral iron chelation therapy.口服铁螯合疗法的前景。

J Lab Clin Med. 1994 Apr;123(4):492-4.

An oral treatment for iron overload in thalassemia?

Hepatology. 1996 Feb;23(2):380-2. doi: 10.1002/hep.510230229.

Iron chelation.

Prog Clin Biol Res. 1989;309:133-40.

[Iron-chelating treatment].

Haematologica. 1989 Oct;74(5 Suppl):241-51.

Cardiac iron removal and functional cardiac improvement by different iron chelation regimens in thalassemia major patients.不同铁螯合方案对重型地中海贫血患者心脏铁去除和心功能改善的作用。

Ann Hematol. 2012 Sep;91(9):1443-9. doi: 10.1007/s00277-012-1480-8. Epub 2012 May 10.

Iron chelation-afforded cardioprotection against chronic anthracycline cardiotoxicity: a study of salicylaldehyde isonicotinoyl hydrazone (SIH).铁螯合对慢性蒽环类药物心脏毒性的心脏保护作用：水杨醛异烟酰腙（SIH）的研究

Toxicology. 2007 Jun 25;235(3):150-66. doi: 10.1016/j.tox.2007.03.020. Epub 2007 Mar 24.

引用本文的文献

Salvage Structures, Known as Iron Chelating Agents, Acquired from the Nature and Matured in the Labs.从自然界获取并在实验室中完善的挽救结构，即铁螯合剂。

Curr Med Chem. 2025;32(21):4225-4258. doi: 10.2174/0109298673264118231228042816.

Computer-aided design of novel antibacterial 3-hydroxypyridine-4-ones: application of QSAR methods based on the MOLMAP approach.新型抗菌 3-羟基吡啶-4-酮的计算机辅助设计：基于 MOLMAP 方法的定量构效关系方法的应用。

J Comput Aided Mol Des. 2012 Mar;26(3):349-61. doi: 10.1007/s10822-012-9561-2. Epub 2012 Mar 28.

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Iron chelation afforded cardioprotection against H2O2-induced H9C2 cell injury: application of novel 3-hydroxy pyridine-4-one derivatives.

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