Armstrong David G, Cohen Kelman, Courric Stephane, Bharara Manish, Marston William
Southern Arizona Limb Salvage Alliance, University of Arizona College of Medicine, Tucson, Arizona 85724 , USA.
J Diabetes Sci Technol. 2011 Nov 1;5(6):1591-5. doi: 10.1177/193229681100500636.
Diabetic foot complications are increasing in prevalence worldwide. Care and attention to these complications have improved greatly. Many advanced therapies are now being investigated or taken through final stages of clinical studies worldwide. However, the data upon which assumptions regarding morbidity, healing, and mortality have been based are grossly outdated. The purpose of this brief article is to report on current data regarding neuropathic and neuroischemic wounds and to propose that the latter category of advanced-stage diabetic foot wound may now be emerging as the most commonly encountered lesion in the developed world. Unfortunately, it is still systematically excluded from most clinical study criteria. Additionally, just as in the care of cancer, we call for therapy of these advanced-stage diabetic foot ulcers to be managed in similarly interdisciplinary centers where patients may have access to potentially beneficial clinical trials.
糖尿病足并发症在全球范围内的患病率正在上升。对这些并发症的护理和关注已经有了很大改善。目前，许多先进疗法正在全球范围内进行研究或处于临床研究的最后阶段。然而，此前用于假设发病率、愈合情况和死亡率的数据已经严重过时。这篇短文的目的是报告有关神经性和神经缺血性伤口的当前数据，并提出后一类晚期糖尿病足伤口可能正在成为发达国家最常见的病变。不幸的是，它仍然被大多数临床研究标准系统地排除在外。此外，就像癌症护理一样，我们呼吁在类似的跨学科中心对这些晚期糖尿病足溃疡进行治疗，患者在这些中心可能有机会参与潜在有益的临床试验。
