白细胞介素-21 与干燥综合征。
IL-21 and Sjögren's syndrome.
出版信息
Arthritis Res Ther. 2011;13(6):137. doi: 10.1186/ar3518. Epub 2011 Dec 19.
Abstract
Treatment of Sjögren's syndrome is almost entirely symptomatic. A lack of true understanding of the underlying immunological pathology of the disease prevents directed therapy. Interleukin-21 (IL-21) is elevated in the serum of patients with this disease and is expressed by the lymphocytes infiltrating the salivary glands. The known functions of IL-21 in facilitating differentiation, proliferation, and survival of both B and T cells mesh well with the findings in Sjögren's syndrome. Demonstration of IL-21 as a fundamental aspect of the pathophysiology of Sjögren's syndrome could lead to the development of anti-IL-21 therapy for this disease.
摘要
干燥综合征的治疗几乎完全是对症的。由于对疾病潜在免疫病理学缺乏真正的了解，无法进行针对性治疗。这种疾病患者的血清中白细胞介素 21（IL-21）升高，并由浸润唾液腺的淋巴细胞表达。IL-21 在促进 B 和 T 细胞的分化、增殖和存活方面的已知功能与干燥综合征的发现非常吻合。IL-21 作为干燥综合征病理生理学基础的一个方面的证明，可能会导致针对这种疾病的抗 IL-21 治疗的发展。
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