Agence Nationale de Sécurité Sanitaire (Anses), Unité Epidémiologie et Bien-Etre du Porc, B.P. 53, 22440 Ploufragan, France.
Vet Microbiol. 2012 May 25;157(1-2):152-63. doi: 10.1016/j.vetmic.2011.12.015. Epub 2011 Dec 19.
A study was carried out in 125 farrow-to-finish pig herds to assess the relationships between pathogens involved in respiratory disorders and to relate these findings to clinical signs of respiratory diseases and pneumonia and pleuritis at slaughter. Clinical examination and sampling were carried out on four different batches in each herd (pigs aged 4, 10, 16 and 22 weeks). Mycoplasma hyopneumoniae, Actinobacillus pleuropneumoniae, swine influenza viruses (SIV), porcine reproductive and respiratory syndrome virus (PRRSV) and porcine circovirus type 2 (PCV2) were detected by serological or PCR tests. Pneumonia-like gross lesions and pleuritis were scored at the slaughterhouse. The results indicate that the percentage of pigs PCR-positive for PCV2 at 4, 10 and 16 weeks old was associated with the percentage of pigs PCR-positive for M. hyopneumoniae at these ages. On the other hand, the percentage of pigs with antibodies against PRRSV at 10, 16 and 22 weeks was positively correlated with the percentage of pigs seropositive for M. hyopneumoniae at 22 weeks, with the percentage of pigs with antibodies against SIV H1N1 and SIV H1N2 and the percentage of pigs sero-positive for A. pleuropneumoniae serotype 2. The findings also indicate that, within the five studied pathogens, M. hyopneumoniae, PRRSV and SIV H1N1 are the major pathogens involved in pneumonia-like gross lesions even though PCV2 may play a role. A. pleuropneumoniae serotype 2, in association with PRRSV, is significantly associated with extensive pleuritis. Respiratory diseases could be significantly reduced by implementing measures including appropriate management practices to control these pathogens.
一项针对 125 个育肥猪群的研究旨在评估与呼吸道疾病相关的病原体之间的关系，并将这些发现与呼吸道疾病和屠宰时肺炎和胸膜炎的临床症状相关联。在每个猪群中进行了四次不同批次的临床检查和采样（4、10、16 和 22 周龄的猪）。通过血清学或 PCR 检测检测了支原体肺炎、胸膜肺炎放线杆菌、猪流感病毒（SIV）、猪繁殖与呼吸综合征病毒（PRRSV）和猪圆环病毒 2 型（PCV2）。在屠宰场对肺炎样大体病变和胸膜炎进行评分。结果表明，4、10 和 16 周龄时 PCV2 阳性猪的百分比与这些年龄段时支原体肺炎阳性猪的百分比相关。另一方面，10、16 和 22 周龄时抗 PRRSV 抗体阳性的猪的百分比与 22 周龄时支原体肺炎血清阳性猪的百分比呈正相关，与抗 SIV H1N1 和 SIV H1N2 抗体阳性的猪的百分比以及血清阳性的胸膜肺炎放线杆菌 2 型血清阳性的猪的百分比相关。研究结果还表明，在所研究的五种病原体中，支原体肺炎、PRRSV 和 SIV H1N1 是引起肺炎样大体病变的主要病原体，尽管 PCV2 可能起作用。胸膜肺炎放线杆菌 2 型与 PRRSV 相关，与广泛的胸膜炎显著相关。通过实施包括适当管理措施在内的措施，可以显著减少呼吸道疾病，以控制这些病原体。
