NMR Research Centre, Indian Institute of Science, Bangalore 560 012, India.
J Magn Reson. 2012 Feb;215:23-6. doi: 10.1016/j.jmr.2011.12.008. Epub 2011 Dec 21.
The present study reports a two dimensional NMR experiment which separates single quantum spectra of enantiomers from that of a racemic mixture. This is a blend of selective double quantum refocusing, for resolving couplings and chemical shift interactions along two dimensions followed by correlation of the selectively excited protons to the entire coupled spin network. The concept is solely based on the presence of distinct intra methyl dipolar couplings of different enantiomers when dissolved in chiral orienting media. The analysis of single enantiomer spectrum obtained from respective F(2) cross sections yield all the spectral information.
本研究报告了一种二维 NMR 实验，可将对映异构体的单量子谱与外消旋混合物的单量子谱分离。这是选择性双量子重聚焦的混合，用于沿两个维度分辨耦合和化学位移相互作用，然后将选择性激发的质子与整个偶联自旋网络相关联。该概念完全基于当溶解在手性导向介质中时不同对映异构体的独特的甲基内偶极耦合的存在。从各自的 F2 截面获得的单对映异构体光谱的分析可提供所有光谱信息。
