Laboratory of Drug Addiction, Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smętna 12, 31-343 Krakow, Poland.
Eur J Pharmacol. 2012 Feb 29;677(1-3):111-5. doi: 10.1016/j.ejphar.2011.12.033. Epub 2011 Dec 29.
A number of data indicate that serotonin (5-HT) 5-HT(1B) receptor ligands affect the behavioral effects of psychostimulants. In the present study we examined effects of the selective 5-HT(1B) receptor antagonist N-[3-[3-(dimethylamino)ethoxy]-4-methoxyphenyl]-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-carboxamide hydrochloride (SB 216641) and the agonist 5-propoxy-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-pyrrolo[3,2-b]pyridine hydrochloride (CP 94253) on amphetamine self-administration in rats. SB 216641 administered in doses of 2.5-7.5 mg/kg did not affect the self-administration of amphetamine injected in unit doses of 0.06 or 0.12 mg/kg/infusion. On the other hand, CP 94253 administered in doses of 2.5 or 5 mg/kg attenuated amphetamine self-administration, yet the effect of 2.5 mg/kg of the agonist was fairly weak and significant only in case of a higher unit dose of the psychostimulant. The inhibitory effect of CP 94253 administered in a dose of 5mg/kg on the self-administration of amphetamine injected in a unit dose of 0.06 mg/kg/infusion was significantly reduced by SB 216641 administrated in a dose of 7.5 mg/kg. These results indicate that tonic activation of 5-HT(1B) receptors is not involved in the self-administration of amphetamine, while pharmacological stimulation of these receptors attenuates this behavioral phenomenon.
一些数据表明，5-羟色胺（5-HT）5-HT（1B）受体配体影响精神兴奋剂的行为效应。在本研究中，我们研究了选择性 5-HT（1B）受体拮抗剂 N-[3-[3-（二甲氨基）乙氧基]-4-甲氧基苯基]-2'-甲基-4'-(5-甲基-1,2,4-恶二唑-3-基）-[1,1'-联苯]-4-羧酰胺盐酸盐（SB 216641）和激动剂 5-丙氧基-3-(1,2,3,6-四氢-4-吡啶基)-1H-吡咯并[3,2-b]吡啶盐酸盐（CP 94253）对大鼠安非他命自我给药的影响。2.5-7.5mg/kg 的 SB 216641 剂量不影响 0.06 或 0.12mg/kg/ 次单位剂量的安非他命的自我给药。另一方面，2.5 或 5mg/kg 的 CP 94253 剂量减轻了安非他命的自我给药，但激动剂 2.5mg/kg 的作用相当微弱，仅在更高的精神兴奋剂单位剂量的情况下才具有统计学意义。5mg/kg 的 CP 94253 对 0.06mg/kg/ 次单位剂量安非他命自我给药的抑制作用，被 7.5mg/kg 的 SB 216641 显著减弱。这些结果表明，5-HT（1B）受体的紧张性激活不参与安非他命的自我给药，而这些受体的药理学刺激减轻了这种行为现象。
