HIV 治疗即预防和 HPTN 052。
HIV treatment as prevention and HPTN 052.
机构信息
Division of Infectious Diseases, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
出版信息
Curr Opin HIV AIDS. 2012 Mar;7(2):99-105. doi: 10.1097/COH.0b013e32834f5cf2.
Abstract
PURPOSE OF REVIEW
This review summarizes the development and implementation of a large clinical trial, HIV Prevention Trials Network (HPTN) 052, whose initial results were recently presented and published.
RECENT FINDINGS
A randomized, clinical trial demonstrated that antiretroviral therapy reduces the sexual transmission of HIV in HIV-serodiscordant couples by more than 96%. The logistical challenges in preparing for and conducting such a trial were considerable.
SUMMARY
HPTN 052 required many years of preparation, considerable collaboration between National Institute of Health and six pharmaceutical companies, and careful ongoing consideration of a large number of ethical issues. HPTN 052 revealed the magnitude of benefit when using antiretroviral therapy to prevent the transmission of HIV, and served as proof of a concept. The results have proven central to the development of new global HIV-prevention efforts.
摘要
目的综述
本文总结了一项大型临床试验——艾滋病预防试验网络（HIV Prevention Trials Network，HPTN）052 的开展和实施情况，该试验的初步结果最近公布。
最新发现
一项随机临床试验表明，抗逆转录病毒疗法可使 HIV 血清不一致的夫妇间 HIV 的性传播减少 96%以上。为准备和开展此类试验而面临的后勤挑战相当大。
总结
HPTN 052 试验需要多年的筹备，美国国立卫生研究院与六家制药公司之间进行了大量合作，并持续认真考虑了许多伦理问题。HPTN 052 试验揭示了使用抗逆转录病毒疗法预防 HIV 传播的巨大益处，也证明了这一概念。其结果是新的全球 HIV 预防工作的核心。
相似文献
1
HIV treatment as prevention and HPTN 052.HIV 治疗即预防和 HPTN 052。
Curr Opin HIV AIDS. 2012 Mar;7(2):99-105. doi: 10.1097/COH.0b013e32834f5cf2.
2
Reaping the prevention benefits of highly active antiretroviral treatment: policy implications of HIV Prevention Trials Network 052.从高效抗逆转录病毒治疗中收获预防效益：HIV 预防试验网络 052 的政策意义。
Curr Opin HIV AIDS. 2012 Mar;7(2):111-6. doi: 10.1097/COH.0b013e32834fcff6.
3
Preventing HIV transmission through antiretroviral treatment-mediated virologic suppression: aspects of an emerging scientific agenda.通过抗逆转录病毒治疗介导的病毒学抑制预防 HIV 传播：新兴科学议程的各个方面。
Curr Opin HIV AIDS. 2012 Mar;7(2):106-10. doi: 10.1097/COH.0b013e32834f3f13.
4
Prevention of HIV Transmission and the HPTN 052 Study.预防 HIV 传播和 HPTN 052 研究。
Annu Rev Med. 2020 Jan 27;71:347-360. doi: 10.1146/annurev-med-110918-034551. Epub 2019 Oct 25.
5
Antiretroviral Therapy to Prevent HIV Acquisition in Serodiscordant Couples in a Hyperendemic Community in Rural South Africa.在南非农村高流行社区中，采用抗逆转录病毒疗法预防血清学不一致伴侣感染艾滋病毒
Clin Infect Dis. 2016 Aug 15;63(4):548-54. doi: 10.1093/cid/ciw335. Epub 2016 May 20.
6
Prevention of HIV-1 infection with early antiretroviral therapy.早期抗逆转录病毒疗法预防 HIV-1 感染。
N Engl J Med. 2011 Aug 11;365(6):493-505. doi: 10.1056/NEJMoa1105243. Epub 2011 Jul 18.
7
Antiretroviral treatment of HIV-1 prevents transmission of HIV-1: where do we go from here?抗逆转录病毒治疗 HIV-1 可预防 HIV-1 的传播：我们下一步该怎么做？
Lancet. 2013 Nov 2;382(9903):1515-24. doi: 10.1016/S0140-6736(13)61998-4. Epub 2013 Oct 23.
8
Couples HIV testing and immediate antiretroviral therapy for serodiscordant HIV-positive partners: Translating evidence into programme in Vietnam.夫妻艾滋病毒检测及为血清学不一致的艾滋病毒阳性伴侣立即提供抗逆转录病毒治疗：在越南将证据转化为项目实践
Int J STD AIDS. 2019 Jul;30(8):739-747. doi: 10.1177/0956462418825405. Epub 2019 May 2.
9
Antiretroviral Therapy for the Prevention of HIV-1 Transmission.抗逆转录病毒疗法预防HIV-1传播
N Engl J Med. 2016 Sep 1;375(9):830-9. doi: 10.1056/NEJMoa1600693. Epub 2016 Jul 18.
10
Adherence to Early Antiretroviral Therapy: Results From HPTN 052, a Phase III, Multinational Randomized Trial of ART to Prevent HIV-1 Sexual Transmission in Serodiscordant Couples.坚持早期抗逆转录病毒治疗：HPTN 052研究结果，一项关于抗逆转录病毒治疗预防血清学不一致伴侣间HIV-1性传播的III期多国随机试验
J Acquir Immune Defic Syndr. 2015 Jun 1;69(2):234-40. doi: 10.1097/QAI.0000000000000593.
引用本文的文献
1
The Longitudinal Impact of Psychosocial Syndemic Variables on Adherence to Antiretroviral Therapy Among People With HIV in Brazil, Thailand, and Zambia: An Analysis by HIV Transmission Groups in HPTN 063.心理社会综合征变量对巴西、泰国和赞比亚艾滋病毒感染者抗逆转录病毒治疗依从性的纵向影响：HPTN 063中按艾滋病毒传播群体进行的分析
AIDS Educ Prev. 2025 Apr;37(2):89-106. doi: 10.1521/aeap.2025.37.2.89.
2
A Remote Intervention Based on mHealth and Community Health Workers for Antiretroviral Therapy Adherence in People With HIV: Pilot Randomized Controlled Trial.一项基于移动健康和社区卫生工作者的远程干预措施对HIV感染者抗逆转录病毒治疗依从性的影响：随机对照试验试点研究
JMIR Form Res. 2025 Apr 2;9:e67997. doi: 10.2196/67997.
3
Urban, formerly incarcerated, black, heterosexual men with substance use disorders: eligible for pre-exposure prophylaxis (PrEP) but unaware of their vulnerability to HIV acquisition.有药物使用障碍的城市地区曾被监禁的黑人异性恋男性：符合暴露前预防（PrEP）条件，但未意识到自己易感染艾滋病毒。
AIDS Care. 2025 Mar;37(3):445-454. doi: 10.1080/09540121.2024.2445792. Epub 2024 Dec 30.
4
Disruptions to HIV Prevention During Armed Conflict in Ukraine and Other Settings.乌克兰及其他地区武装冲突期间艾滋病预防工作受到的干扰。
Curr HIV/AIDS Rep. 2024 Dec 14;22(1):10. doi: 10.1007/s11904-024-00716-x.
5
Examining the Accuracy of Self-Reported Antiretroviral Therapy Adherence Using a Visual Analog Scale Among Opioid-Dependent People Living with HIV.使用视觉模拟量表评估 HIV 合并阿片类药物依赖者自我报告的抗逆转录病毒治疗依从性的准确性。
AIDS Behav. 2024 Dec;28(12):4046-4051. doi: 10.1007/s10461-024-04526-5. Epub 2024 Nov 6.
6
A Systematic Review and Narrative Synthesis of Factors Affecting Pre-exposure Prophylaxis Willingness Among Black Women for HIV Prevention.影响黑人女性艾滋病毒预防暴露前预防意愿的因素的系统评价与叙述性综合分析
AIDS Behav. 2025 Jan;29(1):101-132. doi: 10.1007/s10461-024-04491-z. Epub 2024 Sep 28.
7
Drivers and Facilitators of HIV-Related Stigma in Healthcare Settings in Ireland.爱尔兰医疗环境中与艾滋病毒相关耻辱感的驱动因素和促进因素。
AIDS Behav. 2025 Jan;29(1):22-36. doi: 10.1007/s10461-024-04489-7. Epub 2024 Sep 13.
8
Development and evaluation of a high-sensitivity RT-PCR lateral flow assay for early detection of HIV-1 infection.用于早期检测HIV-1感染的高灵敏度逆转录聚合酶链反应侧向流动检测法的开发与评估
Heliyon. 2024 Jun 12;10(12):e32784. doi: 10.1016/j.heliyon.2024.e32784. eCollection 2024 Jun 30.
9
Knowledge of Sexually Transmitted Infections and HIV among People Living with HIV: Should We Be Concerned?艾滋病毒感染者对性传播感染和艾滋病毒的认知：我们应该担忧吗？
Healthcare (Basel). 2024 Feb 6;12(4):417. doi: 10.3390/healthcare12040417.
10
Assessing index CD4 and associated outcomes at 1-year in a tertiary HIV clinic, KwaZulu-Natal.评估夸祖鲁-纳塔尔省一家三级艾滋病毒诊所患者在 1 年内的 CD4 指数及相关结果。
S Afr Fam Pract (2004). 2024 Jan 25;66(1):e1-e7. doi: 10.4102/safp.v66i1.5803.
本文引用的文献
1
Timing of HAART initiation and clinical outcomes in human immunodeficiency virus type 1 seroconverters.1型人类免疫缺陷病毒血清转化者开始高效抗逆转录病毒治疗的时机与临床结局
Arch Intern Med. 2011 Sep 26;171(17):1560-9. doi: 10.1001/archinternmed.2011.401.
2
Treatment for prevention of HIV transmission in a localised epidemic: the case for South Australia.在局部流行地区预防艾滋病毒传播的治疗方法：以南澳大利亚为例。
Sex Health. 2011 Sep;8(3):280-94. doi: 10.1071/SH10084.
3
Prevention of HIV-1 infection with early antiretroviral therapy.早期抗逆转录病毒疗法预防 HIV-1 感染。
N Engl J Med. 2011 Aug 11;365(6):493-505. doi: 10.1056/NEJMoa1105243. Epub 2011 Jul 18.
4
The role of acute and early HIV infection in the spread of HIV and implications for transmission prevention strategies in Lilongwe, Malawi: a modelling study.在马拉维利隆圭，急性和早期 HIV 感染在 HIV 传播中的作用及其对传播预防策略的影响：一项建模研究。
Lancet. 2011 Jul 16;378(9787):256-68. doi: 10.1016/S0140-6736(11)60842-8.
5
HIV-1 treatment as prevention: the good, the bad, and the challenges.HIV-1 治疗即预防：好的、坏的和挑战。
Curr Opin HIV AIDS. 2011 Jul;6(4):315-25. doi: 10.1097/COH.0b013e32834788e7.
6
HIV treatment for prevention.HIV 治疗用于预防。
J Int AIDS Soc. 2011 May 25;14:28. doi: 10.1186/1758-2652-14-28.
7
Antiretroviral therapy for prevention of HIV transmission in HIV-discordant couples.抗逆转录病毒疗法用于预防HIV抗体不一致伴侣间的HIV传播。
Cochrane Database Syst Rev. 2011 May 11(5):CD009153. doi: 10.1002/14651858.CD009153.
8
When to initiate combined antiretroviral therapy to reduce mortality and AIDS-defining illness in HIV-infected persons in developed countries: an observational study.在发达国家，何时开始联合抗逆转录病毒疗法以降低 HIV 感染者的死亡率和艾滋病定义性疾病：一项观察性研究。
Ann Intern Med. 2011 Apr 19;154(8):509-15. doi: 10.7326/0003-4819-154-8-201104190-00001.
9
Quality of life among individuals with HIV starting antiretroviral therapy in diverse resource-limited areas of the world.在全球资源有限的不同地区开始接受抗逆转录病毒治疗的 HIV 感染者的生活质量。
AIDS Behav. 2012 Feb;16(2):266-77. doi: 10.1007/s10461-011-9947-5.
10
The effect of expanded antiretroviral treatment strategies on the HIV epidemic among men who have sex with men in San Francisco.扩大抗逆转录病毒治疗策略对旧金山男男性行为者中 HIV 流行的影响。
Clin Infect Dis. 2011 Apr 15;52(8):1046-9. doi: 10.1093/cid/cir085.
Zotero 插件