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Tumor strengths and frailties: Cancer SUMmOns Otto's metabolism.

作者信息

Ohh Michael

机构信息

University of Toronto, Toronto, Ontario, Canada.

出版信息

Nat Med. 2012 Jan 6;18(1):30-1. doi: 10.1038/nm.2631.

DOI:10.1038/nm.2631
PMID:22227664
Abstract
摘要

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Analyses of the transcriptome and metabolome demonstrate that HIF1α mediates altered tumor metabolism in clear cell renal cell carcinoma.转录组和代谢组分析表明，HIF1α介导透明细胞肾细胞癌中肿瘤代谢的改变。
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Microphthalmia-associated transcription factor, melanoma, and renal carcinoma: the small ubiquitin-like modifier connection.小眼畸形相关转录因子、黑色素瘤和肾癌：小泛素样修饰物的联系
Pigment Cell Melanoma Res. 2011 Dec;24(6):1079-80. doi: 10.1111/j.1755-148X.2011.00925.x.
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本文引用的文献

1
A SUMOylation-defective MITF germline mutation predisposes to melanoma and renal carcinoma.一个 SUMOylation 缺陷的 MITF 种系突变易导致黑色素瘤和肾细胞癌。
Nature. 2011 Oct 19;480(7375):94-8. doi: 10.1038/nature10539.
2
Inhibition of NEDD8-activating enzyme: a novel approach for the treatment of acute myeloid leukemia.抑制 NEDD8-激活酶：治疗急性髓系白血病的新方法。
Blood. 2010 May 6;115(18):3796-800. doi: 10.1182/blood-2009-11-254862. Epub 2010 Mar 4.
3
SDH5, a gene required for flavination of succinate dehydrogenase, is mutated in paraganglioma.
人类原代成肌细胞的增殖与体内外衰老依赖性的能量代谢改变有关。
Oxid Med Cell Longev. 2016;2016:8296150. doi: 10.1155/2016/8296150. Epub 2016 Jan 5.
4
Maternal bile acid transporter deficiency promotes neonatal demise.母体胆汁酸转运体缺乏会导致新生儿死亡。
Nat Commun. 2015 Sep 29;6:8186. doi: 10.1038/ncomms9186.
5
Membrane transporters for the special amino acid glutamine: structure/function relationships and relevance to human health.特殊氨基酸谷氨酰胺的膜转运体：结构/功能关系及其与人类健康的相关性。
Front Chem. 2014 Aug 11;2:61. doi: 10.3389/fchem.2014.00061. eCollection 2014.
SDH5是琥珀酸脱氢酶黄素化所需的基因，在副神经节瘤中发生突变。
Science. 2009 Aug 28;325(5944):1139-42. doi: 10.1126/science.1175689. Epub 2009 Jul 23.
4
An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer.一种NEDD8激活酶抑制剂作为治疗癌症的新方法。
Nature. 2009 Apr 9;458(7239):732-6. doi: 10.1038/nature07884.
5
Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway.后生动物的氧感应：HIF羟化酶途径的核心作用。
Mol Cell. 2008 May 23;30(4):393-402. doi: 10.1016/j.molcel.2008.04.009.
6
SUMO-specific protease 1 is essential for stabilization of HIF1alpha during hypoxia.SUMO特异性蛋白酶1在缺氧期间对HIF1α的稳定至关重要。
Cell. 2007 Nov 2;131(3):584-95. doi: 10.1016/j.cell.2007.08.045.
7
Life with oxygen.有氧生活。
Science. 2007 Oct 5;318(5847):62-4. doi: 10.1126/science.1147949.
8
Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma.综合基因组分析确定MITF为恶性黑色素瘤中扩增的谱系存活癌基因。
Nature. 2005 Jul 7;436(7047):117-22. doi: 10.1038/nature03664.
9
On the origin of cancer cells.论癌细胞的起源。
Science. 1956 Feb 24;123(3191):309-14. doi: 10.1126/science.123.3191.309.
10
Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer.FH基因的种系突变易导致显性遗传的子宫肌瘤、皮肤平滑肌瘤和乳头状肾细胞癌。
Nat Genet. 2002 Apr;30(4):406-10. doi: 10.1038/ng849. Epub 2002 Feb 25.