Division of Emergency Medicine, The Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
Pediatr Infect Dis J. 2012 May;31(5):534-6. doi: 10.1097/INF.0b013e3182480fed.
The incidence of pneumococcal disease in sickle cell disease declined significantly with penicillin prophylaxis as well as with the pneumococcal polysaccharide and heptavalent conjugate vaccines. In this report, we describe our experience with pneumococcal bacteremia in pediatric patients with sickle cell disease in the post-heptavalent pneumococcal conjugate vaccine era. Despite established prophylactic strategies, pneumococcal bacteremia continues to occur in patients with sickle cell disease.
青霉素预防以及肺炎球菌多糖和 7 价结合疫苗的应用显著降低了镰状细胞病患者中肺炎球菌疾病的发病率。在本报告中，我们描述了 7 价肺炎球菌结合疫苗时代镰状细胞病儿科患者中肺炎球菌菌血症的发病经验。尽管已有既定的预防策略，但镰状细胞病患者仍会发生肺炎球菌菌血症。
