Abstract
A review of reproductive biology and oncologic immunology reveals striking similarities between the tolerance of neoantigen as demonstrated in pregnancy and cancer. The author discusses the phylogeny of sexual reproduction and the oncologic condition, and suggests that an evolved mechanism of acquired tolerance to HLA-incompatible tissue necessitated by sexual reproduction consequently provides a mechanism for the tolerance of cancer.
摘要
对生殖生物学和肿瘤免疫学的综述揭示了妊娠和癌症中所表现出的新抗原耐受性之间的惊人相似之处。作者讨论了有性生殖和肿瘤状态的系统发育，并提出，有性生殖所必需的对HLA不相容组织获得性耐受性的进化机制，因此为癌症耐受性提供了一种机制。
Zotero 插件