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Growth inhibitory effect of 4-phenyl butyric acid on human gastric cancer cells is associated with cell cycle arrest.4- 苯基丁酸对人胃癌细胞的生长抑制作用与细胞周期阻滞有关。
World J Gastroenterol. 2012 Jan 7;18(1):79-83. doi: 10.3748/wjg.v18.i1.79.
2
4-phenylbutyric acid promotes migration of gastric cancer cells by histone deacetylase inhibition-mediated IL-8 upregulation.4-苯基丁酸通过组蛋白去乙酰化酶抑制介导的白细胞介素-8上调促进胃癌细胞迁移。
Epigenetics. 2020 Jun-Jul;15(6-7):632-645. doi: 10.1080/15592294.2019.1700032. Epub 2019 Dec 9.
3
Phenylbutyrate-a pan-HDAC inhibitor-suppresses proliferation of glioblastoma LN-229 cell line.苯丁酸盐（一种泛组蛋白去乙酰化酶抑制剂）可抑制胶质母细胞瘤LN - 229细胞系的增殖。
Tumour Biol. 2016 Jan;37(1):931-42. doi: 10.1007/s13277-015-3781-8. Epub 2015 Aug 11.
4
4-Phenybutyric acid promotes gastric cancer cell migration via histone deacetylase inhibition-mediated HER3/HER4 up-regulation.4-苯丁酸通过组蛋白去乙酰化酶抑制介导的 HER3/HER4 上调促进胃癌细胞迁移。
Cell Biol Int. 2018 Jan;42(1):53-62. doi: 10.1002/cbin.10866. Epub 2017 Oct 9.
5
Growth inhibition and cell-cycle arrest of human gastric cancer cells by Lycium barbarum polysaccharide.枸杞多糖对人胃癌细胞的生长抑制和细胞周期阻滞作用。
Med Oncol. 2010 Sep;27(3):785-90. doi: 10.1007/s12032-009-9286-9. Epub 2009 Aug 11.
6
Synthetic retinoid CD437 induces cell-dependent cycle arrest by differential regulation of cell cycle associated proteins.合成维甲酸CD437通过对细胞周期相关蛋白的差异调节诱导细胞依赖性周期停滞。
Anticancer Res. 2002 Sep-Oct;22(5):2757-64.
7
Effect of bone morphogenetic protein-2 on proliferation and apoptosis of gastric cancer cells.骨形态发生蛋白-2 对胃癌细胞增殖和凋亡的影响。
Int J Med Sci. 2012;9(2):184-92. doi: 10.7150/ijms.3859. Epub 2012 Feb 15.
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Naturally occurring aesculetin coumarin exerts antiproliferative effects in gastric cancer cells mediated via apoptotic cell death, cell cycle arrest and targeting PI3K/AKT/M-TOR signalling pathway.天然的七叶内酯香豆素通过诱导细胞凋亡、细胞周期阻滞和靶向 PI3K/AKT/M-TOR 信号通路，对胃癌细胞发挥抗增殖作用。
Acta Biochim Pol. 2021 Mar 17;68(1):109-113. doi: 10.18388/abp.2020_5463.
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G(1) Phase growth arrest and induction of p21(Waf1/Cip1/Sdi1) in IB3-1 cells treated with 4-sodium phenylbutyrate.用4-苯丁酸钠处理的IB3-1细胞中G(1)期生长停滞及p21（Waf1/Cip1/Sdi1）的诱导
J Pharmacol Exp Ther. 2000 Sep;294(3):941-7.
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[Effect of staurosporine on cell cycle of human gastric cancer cells].[星形孢菌素对人胃癌细胞细胞周期的影响]
Ai Zheng. 2003 Jul;22(7):691-4.
引用本文的文献
1
Development and evaluation of a self-assembled nanoparticle-based prodrug for sustained delivery of 4-phenylbutyric acid.一种用于持续递送4-苯基丁酸的基于自组装纳米颗粒的前药的开发与评估。
Sci Technol Adv Mater. 2025 Mar 24;26(1):2482512. doi: 10.1080/14686996.2025.2482512. eCollection 2025.
2
Phenylbutyrate modulates polyamine acetylase and ameliorates Snyder-Robinson syndrome in a Drosophila model and patient cells.苯丁酸钠调节多胺乙酰基转移酶，改善果蝇模型和患者细胞中的 Snyder-Robinson 综合征。
JCI Insight. 2022 Jul 8;7(13):e158457. doi: 10.1172/jci.insight.158457.
3
Fullerene Derivatives as Lung Cancer Cell Inhibitors: Investigation of Potential Descriptors Using QSAR Approaches.富勒烯衍生物作为肺癌细胞抑制剂的研究：使用 QSAR 方法探讨潜在描述符。
Int J Nanomedicine. 2020 Apr 14;15:2485-2499. doi: 10.2147/IJN.S243463. eCollection 2020.
4
Porcine Circovirus Type 2 Induces ORF3-Independent Mitochondrial Apoptosis via PERK Activation and Elevation of Cytosolic Calcium.猪圆环病毒 2 型通过 PERK 激活和细胞浆钙升高诱导 ORF3 非依赖性线粒体凋亡。
J Virol. 2019 Mar 21;93(7). doi: 10.1128/JVI.01784-18. Print 2019 Apr 1.
5
Chemical chaperone, TUDCA unlike PBA, mitigates protein aggregation efficiently and resists ER and non-ER stress induced HepG2 cell death.化学伴侣 TUDCA 与 PBA 不同，能有效减轻蛋白质聚集，并抵抗内质网和非内质网应激诱导的 HepG2 细胞死亡。
Sci Rep. 2017 Jun 19;7(1):3831. doi: 10.1038/s41598-017-03940-1.
6
Porcine Circovirus 2 Deploys PERK Pathway and GRP78 for Its Enhanced Replication in PK-15 Cells.猪圆环病毒2利用PERK途径和GRP78在PK-15细胞中增强复制。
Viruses. 2016 Feb 20;8(2):56. doi: 10.3390/v8020056.
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Cytoplasmic Drosha Is Aberrant in Precancerous Lesions of Gastric Carcinoma and Its Loss Predicts Worse Outcome for Gastric Cancer Patients.细胞质中的 Drosha 在胃癌癌前病变中异常，其缺失预示着胃癌患者更差的预后。
Dig Dis Sci. 2016 Apr;61(4):1080-90. doi: 10.1007/s10620-015-3986-0. Epub 2015 Dec 22.
8
Phenylbutyrate-a pan-HDAC inhibitor-suppresses proliferation of glioblastoma LN-229 cell line.苯丁酸盐（一种泛组蛋白去乙酰化酶抑制剂）可抑制胶质母细胞瘤LN - 229细胞系的增殖。
Tumour Biol. 2016 Jan;37(1):931-42. doi: 10.1007/s13277-015-3781-8. Epub 2015 Aug 11.
9
Phenylbutyrate Is Bacteriostatic against Mycobacterium tuberculosis and Regulates the Macrophage Response to Infection, Synergistically with 25-Hydroxy-Vitamin D3.苯丁酸盐对结核分枝杆菌具有抑菌作用，并与25-羟基维生素D3协同调节巨噬细胞对感染的反应。
PLoS Pathog. 2015 Jul 2;11(7):e1005007. doi: 10.1371/journal.ppat.1005007. eCollection 2015 Jul.
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Elevated endoplasmic reticulum stress reinforced immunosuppression in the tumor microenvironment via myeloid-derived suppressor cells.内质网应激增强通过髓源性抑制细胞加剧肿瘤微环境中的免疫抑制。
Oncotarget. 2014 Dec 15;5(23):12331-45. doi: 10.18632/oncotarget.2589.
本文引用的文献
1
Global cancer statistics.全球癌症统计数据。
CA Cancer J Clin. 2011 Mar-Apr;61(2):69-90. doi: 10.3322/caac.20107. Epub 2011 Feb 4.
2
The G1 phase arrest and apoptosis by intrinsic pathway induced by valproic acid inhibit proliferation of BGC-823 gastric carcinoma cells.丙戊酸诱导的G1期阻滞和内源性途径凋亡抑制BGC-823胃癌细胞的增殖。
Tumour Biol. 2011 Apr;32(2):335-46. doi: 10.1007/s13277-010-0126-5. Epub 2010 Nov 27.
3
Epigenetics and cancer treatment.表观遗传学与癌症治疗。
Eur J Pharmacol. 2009 Dec 25;625(1-3):131-42. doi: 10.1016/j.ejphar.2009.10.011. Epub 2009 Oct 18.
4
Growth inhibition and cell-cycle arrest of human gastric cancer cells by Lycium barbarum polysaccharide.枸杞多糖对人胃癌细胞的生长抑制和细胞周期阻滞作用。
Med Oncol. 2010 Sep;27(3):785-90. doi: 10.1007/s12032-009-9286-9. Epub 2009 Aug 11.
5
Protein acetylation and histone deacetylase expression associated with malignant breast cancer progression.蛋白质乙酰化和组蛋白去乙酰化酶表达与恶性乳腺癌进展相关。
Clin Cancer Res. 2009 May 1;15(9):3163-71. doi: 10.1158/1078-0432.CCR-08-2319. Epub 2009 Apr 21.
6
Differential expression of microRNA species in human gastric cancer versus non-tumorous tissues.人类胃癌组织与非肿瘤组织中微小RNA种类的差异表达
J Gastroenterol Hepatol. 2009 Apr;24(4):652-7. doi: 10.1111/j.1440-1746.2008.05666.x. Epub 2008 Nov 3.
7
Valproic acid resensitizes cisplatin-resistant ovarian cancer cells.丙戊酸使顺铂耐药的卵巢癌细胞重新敏感化。
Cancer Sci. 2008 Jun;99(6):1218-26. doi: 10.1111/j.1349-7006.2008.00793.x. Epub 2008 Apr 21.
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Methylation of tumor-related genes in neoadjuvant-treated gastric cancer: relation to therapy response and clinicopathologic and molecular features.新辅助治疗的胃癌中肿瘤相关基因的甲基化：与治疗反应及临床病理和分子特征的关系
Clin Cancer Res. 2007 Sep 1;13(17):5095-102. doi: 10.1158/1078-0432.CCR-07-0241.
9
Histone deacetylases and cancer.组蛋白去乙酰化酶与癌症。
Oncogene. 2007 Aug 13;26(37):5420-32. doi: 10.1038/sj.onc.1210610.
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Chemical chaperones reduce endoplasmic reticulum stress and prevent mutant HFE aggregate formation.化学伴侣可减轻内质网应激并防止突变型HFE聚集体形成。
J Biol Chem. 2007 Sep 21;282(38):27905-12. doi: 10.1074/jbc.M702672200. Epub 2007 Jul 11.
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