经阴道给予雌激素疗法的局部效应：综述
Local Effects of Vaginally Administered Estrogen Therapy: A Review.
作者信息
Krause Megan, Wheeler Thomas L, Snyder Thomas E, Richter Holly E
机构信息
University of Kansas Medical Center, Kansas City, KS Department of Obstetrics and Gynecology.
出版信息
J Pelvic Med Surg. 2009 May;15(3):105-114. doi: 10.1097/SPV.0b013e3181ab4804.
Abstract
The results of the Women's Health Initiative (WHI) led to a distinct decline in the routine use of estrogen as preventive therapy for vasomotor symptoms, osteoporosis, and cardiovascular disease in postmenopausal women. Without estrogen replacement, one third of women experience symptoms of atrophic vaginitis including dryness, irritation, itching and or dyspareunia. Local application of estrogen has been shown to relieve these symptoms and improve quality of life for these women. In addition, local estrogen therapy may have a favorable effect on sexuality, urinary tract infections, vaginal surgery, and incontinence. This review examines the effects of vaginally applied estrogen on the vaginal epithelium, urethra and endometrium. An accompanying review examines the systemic effects of vaginally applied estrogen.
摘要
妇女健康倡议（WHI）的结果导致绝经后女性将雌激素作为血管舒缩症状、骨质疏松症和心血管疾病预防性治疗的常规使用显著减少。在没有雌激素替代治疗的情况下，三分之一的女性会出现萎缩性阴道炎症状，包括阴道干燥、刺激、瘙痒和/或性交困难。局部应用雌激素已被证明可缓解这些症状并改善这些女性的生活质量。此外，局部雌激素治疗可能对性功能、尿路感染、阴道手术和尿失禁有积极影响。本综述探讨阴道应用雌激素对阴道上皮、尿道和子宫内膜的影响。另一篇相关综述探讨阴道应用雌激素的全身影响。
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本文引用的文献
1
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Female Pelvic Med Reconstr Surg. 2010 May;16(3):188-95. doi: 10.1097/SPV.0b013e3181d7e86e.
2
A randomized study of low-dose conjugated estrogens on sexual function and quality of life in postmenopausal women.
Menopause. 2009 Mar-Apr;16(2):247-56. doi: 10.1097/gme.0b013e318184c440.
3
Comparison of the effects of hormone therapy regimens, oral and vaginal estradiol, estradiol + drospirenone and tibolone, on sexual function in healthy postmenopausal women.
J Sex Med. 2008 Jan;5(1):132-8. doi: 10.1111/j.1743-6109.2007.00635.x. Epub 2007 Oct 24.
4
The role of local vaginal estrogen for treatment of vaginal atrophy in postmenopausal women: 2007 position statement of The North American Menopause Society.
Menopause. 2007 May-Jun;14(3 Pt 1):355-69; quiz 370-1. doi: 10.1097/gme.0b013e31805170eb.
5
Is endometrial monitoring required with the use of long-term unopposed vaginal estrogen?
Climacteric. 2006 Oct;9(5):321-2. doi: 10.1080/13697130600955229.
6
Practical aspects in the management of vaginal atrophy and sexual dysfunction in perimenopausal and postmenopausal women.
J Sex Med. 2005 Sep;2 Suppl 3:154-65. doi: 10.1111/j.1743-6109.2005.00131.x.
7
A randomized comparative study of the effects of oral and topical estrogen therapy on the lower urinary tract of hysterectomized postmenopausal women.
Fertil Steril. 2006 Jan;85(1):155-60. doi: 10.1016/j.fertnstert.2005.06.042.
8
Testosterone patch for low sexual desire in surgically menopausal women: a randomized trial.
Obstet Gynecol. 2005 May;105(5 Pt 1):944-52. doi: 10.1097/01.AOG.0000158103.27672.0d.
9
Endometrial and vaginal effects of low-dose estradiol delivered by vaginal ring or vaginal tablet.
Climacteric. 2005 Mar;8(1):83-92. doi: 10.1080/13697130500087016.
10
Effects of estrogen with and without progestin on urinary incontinence.
JAMA. 2005 Feb 23;293(8):935-48. doi: 10.1001/jama.293.8.935.
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