Tsuchiya K, Naruse M, Sanaka T, Naruse K, Zeng Z P, Nitta K, Demura H, Shizume K, Sugino N
Department of Medicine, Kidney Center, Tokyo Women's Medical College, Japan.
Am J Hypertens. 1990 Oct;3(10):792-5. doi: 10.1093/ajh/3.10.792.
The effects of endothelin on systemic hemodynamics and renal functions were investigated in anesthetized dogs. Infusion of endothelin at a dose of 1 ng/kg/min decreased renal blood flow and increased renal vascular resistance and filtration fraction. Endothelin at doses higher than 10 ng/kg/min significantly decreased cardiac output, glomerular filtration rate, renal plasma flow, urine volume, and urinary sodium excretion. Mean arterial pressure showed a transient decrease at doses higher than 50 ng/kg/min. These results showed that endothelin in systemic administration has effects on renal functions as well as on systemic hemodynamics.
