Ercin Ersin, Gamsizkan Mehmet, Avsar Serdar
Department of Orthopaedics and Traumatology, Bakirkoy Dr Sadi Konuk Education and Research Hospital, Tevfik Saglam cad. No: 11, 34147,Zuhuratbaba, Istanbul, Turkey.
Orthopedics. 2012 Jan 16;35(1):e120-3. doi: 10.3928/01477447-20111122-32.
High levels of uric acid cause accumulation of monosodium urate crystals. This formation of masses is called tophus. Intraosseous tophus deposits are rare, even for patients with gout. We report an unusual case of intraosseous tophus deposits in the os trigonum. The patient presented with ankle pain with no previous history of gout. On examination, tenderness on the posterior aspect of his ankle and limitation of plantarflexion was noted. Laboratory values were normal, except for an elevated serum uric acid value. Radiographs of the right ankle showed the presence of a large os trigonum with osteosclerotic changes, whereas magnetic resonance imaging showed intraosseous tophus deposits in the os trigonum. Conservative therapy failed, and the patient was admitted for an endoscopic resection of the os trigonum.Intraosseous chalky crystals were detected during endoscopic resection of the os trigonum. The histological diagnosis was tophaceous gout. The underlying pathological mechanism of intraosseous tophi is uncertain. Penetration of urate crystals from the joint due to hyperuricemia may be the mechanism of deposition in this patient.When a patient with hyperuricemia presents with posterior ankle impingement symptoms, intraosseous tophus deposits should be included in the differential diagnosis. Posterior endoscopic excision may be an option for treating intraosseous lesions of the os trigonum because of good visualization, satisfactory excision, and rapid recovery time.
高尿酸水平会导致尿酸单钠晶体的积累。这种团块的形成被称为痛风石。即使对于痛风患者,骨内痛风石沉积也很罕见。我们报告了一例罕见的三角骨内痛风石沉积病例。该患者表现为踝关节疼痛,既往无痛风病史。检查时,发现其踝关节后方压痛,跖屈受限。除血清尿酸值升高外,实验室检查结果均正常。右踝关节X线片显示有一个大的三角骨,伴有骨质硬化改变,而磁共振成像显示三角骨内有痛风石沉积。保守治疗失败后,患者入院接受三角骨内镜切除术。在三角骨内镜切除术中发现了骨内白色晶体。组织学诊断为痛风石性痛风。骨内痛风石的潜在病理机制尚不确定。高尿酸血症导致尿酸盐晶体从关节穿透可能是该患者沉积的机制。当高尿酸血症患者出现踝关节后方撞击症状时,鉴别诊断应包括骨内痛风石沉积。后内侧内镜切除可能是治疗三角骨骨内病变的一种选择,因为其视野良好、切除满意且恢复时间快。