Department of Environmental Sciences, Informatics and Statistics, University Ca' Foscari Venice, Venice, Italy.
Nanotoxicology. 2012 Dec;6:880-98. doi: 10.3109/17435390.2011.626534. Epub 2012 Jan 9.
It has been largely recognised that substantial limitations and uncertainties make the conventional risk assessment (RA) of chemicals unfeasible to apply to engineered nanomaterials (ENMs) today, which leaves the regulators with little support in the near term. The aim of this paper is to discuss the state of the art in the area of the RA of nanomaterials, focusing on the available data and approaches. There is a paucity of reliable information in the online safety databases and the literature is dominated by (eco)toxicity studies, while the nano-exposure research lags behind. Most of the reviewed nano-RA approaches are designed to serve as preliminary risk screening and/or research prioritisation tools and are not intended to support regulatory decision making. In this context, we recommend to further study the possibilities to apply complementary/alternative tools for near-term RA of ENMs in order to facilitate their timely regulation, using the data that are currently available in the literature.
人们已经普遍认识到，大量的局限性和不确定性使得传统的化学品风险评估（RA）在今天无法应用于工程纳米材料（ENMs），这使得监管机构在短期内几乎没有得到支持。本文的目的是讨论纳米材料 RA 领域的最新技术，重点是现有数据和方法。在线安全数据库中可靠信息的缺乏，文献主要由（生态）毒性研究为主，而纳米暴露研究则滞后。大多数审查的纳米 RA 方法旨在作为初步风险筛选和/或研究优先化工具，而不是旨在支持监管决策。在这种情况下，我们建议进一步研究在 ENMs 的近期 RA 中应用补充/替代工具的可能性，以便利用文献中当前可用的数据来促进其及时监管。
