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80 岁以上老人:急性护理和结直肠外科医生面临的日益严峻的挑战。老年急症结直肠手术的结局分析。

Octogenarians: an increasing challenge for acute care and colorectal surgeons. An outcomes analysis of emergency colorectal surgery in the elderly.

机构信息

DEAII-Emergency Department, Sapienza Università di Roma, Umberto I Policlinico di Roma, Rome, Italy.

出版信息

Colorectal Dis. 2012 Jun;14(6):e312-8. doi: 10.1111/j.1463-1318.2012.02934.x.

Abstract

AIM

Emergency surgery is associated with higher mortality rates, especially in elderly patients presenting with emergent colorectal disease. The aim of this study was to determine the outcomes in elderly patients following emergency colorectal resection, with particular focus on octogenarians who presented a sixfold higher mortality rate with respect to other patients.

METHOD

This study examined 355 patients who underwent surgery at an Emergency Department for complications of colorectal disease between January 2007 and December 2009. Morbidity and mortality were analyzed on the basis of patients' characteristics and presentation. Univariate and logistic regression analyses were performed on morbidity and mortality risk factors.

RESULTS

Two-hundred and fifteen patients of > 65 years of age were included, 93 of whom were ≥ 80 years of age. The global mortality rate was 16%. In patients ≥ 80 years of age the mortality rate was 30%. The difference in mortality rate between patients < 80 years of age vs patients ≥ 80 years of age was 24%. In resected patients ≥ 80 years of age, American Society of Anesthesiology grade, colonic ischaemia, neurological comorbidity and anastomotic dehiscence were identified as independent risk factors in both univariate and logistic regression analyses. The morbidity rate was approximately 17%, and no significant difference in morbidity was found between the two groups.

CONCLUSION

The results of this study show that fitness status and micro vascular impairment impact significantly on mortality in the elderly, particularly in octogenarians. Although the outcomes observed were compatible with the literature, the six fold higher mortality rate observed in the most elderly patients identifies a group for which death prevention is best achieved with aggressive resuscitation and intensive postoperative care, rather than timing of surgery.

摘要

目的

急诊手术与更高的死亡率相关,尤其是在出现紧急结直肠疾病的老年患者中。本研究旨在确定接受紧急结直肠切除术后老年患者的结局,特别是关注那些与其他患者相比死亡率高出六倍的 80 岁以上患者。

方法

本研究检查了 2007 年 1 月至 2009 年 12 月期间在急诊科因结直肠疾病并发症而接受手术的 355 名患者。根据患者的特征和表现分析发病率和死亡率。对发病率和死亡率的危险因素进行单因素和逻辑回归分析。

结果

纳入了 215 名>65 岁的患者,其中 93 名患者年龄≥80 岁。总的死亡率为 16%。80 岁以上患者的死亡率为 30%。年龄<80 岁的患者与年龄≥80 岁的患者之间的死亡率差异为 24%。在接受手术的≥80 岁患者中,美国麻醉医师协会分级、结肠缺血、神经合并症和吻合口裂开被确定为单因素和逻辑回归分析中的独立危险因素。发病率约为 17%,两组之间的发病率无显著差异。

结论

本研究结果表明,在老年人中,健康状况和微血管损伤对死亡率有显著影响,特别是在 80 岁以上的老年人中。尽管观察到的结果与文献相符,但在最年长的患者中观察到的六倍高死亡率表明,对于这些患者,最好通过积极的复苏和强化术后护理来预防死亡,而不是手术时机。

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