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吻球囊或边支与主支序贯扩张在分叉部预扩张支架置入术中的应用:来自 micro-CT 和计算模拟的经验。

Kissing balloon or sequential dilation of the side branch and main vessel for provisional stenting of bifurcations: lessons from micro-computed tomography and computational simulations.

机构信息

Department of Bioengineering, Imperial College London, London, United Kingdom.

出版信息

JACC Cardiovasc Interv. 2012 Jan;5(1):47-56. doi: 10.1016/j.jcin.2011.08.019.

Abstract

OBJECTIVES

This study sought to evaluate post-dilation strategies in bifurcation stenting.

BACKGROUND

In bifurcation stenting practice, it is still controversial how post-dilation should be performed and whether the kissing balloon (KB) technique is mandatory when only the main vessel (MV) receives a stent.

METHODS

A series of drug-eluting stents (DES) (n = 26) were deployed in a coronary bifurcation model following a provisional approach. After the deployment of the stent in the MV, post-dilation with the KB technique was compared with a 2-step, sequential post-dilation of the side branch (SB) and MV without kissing.

RESULTS

The percentage of the SB lumen area free of stent struts was similar after KB (79.1 ± 8.7%) and after the 2-step sequence (74.4 ± 11.6%, p = 0.25), a considerable improvement compared with MV stenting only without dilation of the stent at the SB ostium (30.8 ± 7.8%, p < 0.0001). The rate of strut malapposition in the ostium was 21.3 ± 9.2% after KB and 24.9 ± 10.4% after the 2-step sequence, respectively, a significant reduction compared with a simple SB dilation (55.3 ± 16.8%, p < 0.0001) or MV stenting only (47.0 ± 8.5%, p < 0.0005). KB created a significant elliptical overexpansion of the MV lumen, inducing higher stress concentration proximal to the SB. KB also led to a higher risk of incomplete stent apposition at the proximal stent edge (30.7 ± 26.4% vs. 2.8 ± 9.6% for 2-step, p = 0.0016).

CONCLUSIONS

Sequential 2-step post-dilation of the SB and MV may offer a simpler and more efficient alternative to final KB technique for provisional stenting of bifurcations.

摘要

目的

本研究旨在评估分叉支架置入术后的后扩张策略。

背景

在分叉支架置入术中,对于主支血管(MV)置入支架后如何进行后扩张以及是否必须使用双球囊对吻技术(KB)仍存在争议。

方法

采用一种半对吻支架技术在冠状动脉分叉模型中进行一系列药物洗脱支架(DES)的置入。在 MV 中支架置入后,比较了 KB 技术的后扩张与 SB 和 MV 的 2 步序贯后扩张,后者不进行对吻。

结果

KB 后(79.1±8.7%)和 2 步序贯后(74.4±11.6%,p=0.25)SB 管腔面积无支架小梁的比例相似,与单纯 MV 支架置入而 SB 开口处未扩张(30.8±7.8%,p<0.0001)相比有显著改善。KB 后开口处贴壁不良发生率为 21.3±9.2%,2 步序贯后为 24.9±10.4%,与单纯 SB 扩张(55.3±16.8%,p<0.0001)或单纯 MV 支架置入(47.0±8.5%,p<0.0005)相比显著降低。KB 导致 MV 管腔发生明显的椭圆形过度扩张,导致 SB 近端的应力集中增加。KB 还导致近端支架边缘不完全贴壁的风险增加(30.7±26.4% vs. 2.8±9.6%,2 步序贯,p=0.0016)。

结论

对于分叉病变的半对吻支架置入术,SB 和 MV 的 2 步序贯后扩张可能是替代最终 KB 技术的更简单、更有效的方法。

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