Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8560, Japan.
Peptides. 2012 Feb;33(2):346-50. doi: 10.1016/j.peptides.2011.12.011. Epub 2012 Jan 2.
The immunoglobulin heavy chain binding protein (BiP) is an endoplasmic reticulum (ER) chaperone that facilitates the proper folding of newly synthesized secretory and transmembrane proteins. Here we report that BiP mRNA was expressed in the supraoptic nucleus (SON) and paraventricular nucleus (PVN) of the hypothalamus in wild-type mice under basal conditions. Dual in situ hybridization in the SON and PVN demonstrated that BiP mRNA was expressed in almost all the neurons of arginine vasopressin (AVP), an antidiuretic hormone. BiP mRNA expression levels were increased in proportion to AVP mRNA expression in the SON and PVN under dehydration. These data suggest that BiP is involved in the homeostasis of ER function in the AVP neurons in the SON and PVN.
免疫球蛋白重链结合蛋白（BiP）是内质网（ER）伴侣，有助于新合成的分泌蛋白和跨膜蛋白的正确折叠。在这里，我们报告在基础条件下，野生型小鼠的下丘脑视上核（SON）和室旁核（PVN）中表达 BiP mRNA。SON 和 PVN 中的双原位杂交表明，BiP mRNA 几乎在所有抗利尿激素精氨酸血管加压素（AVP）神经元中表达。脱水时，SON 和 PVN 中的 BiP mRNA 表达水平与 AVP mRNA 表达成比例增加。这些数据表明 BiP 参与 SON 和 PVN 中 AVP 神经元的 ER 功能的动态平衡。
