与TIF1α相关的TRIM辅助因子将染色质修饰与转录调控、信号传导及肿瘤抑制联系起来。
The TIF1α-related TRIM cofactors couple chromatin modifications to transcriptional regulation, signaling and tumor suppression.
作者信息
Herquel Benjamin, Ouararhni Khalid, Davidson Irwin
机构信息
Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch Cédex, France.
出版信息
Transcription. 2011 Sep-Oct;2(5):231-6. doi: 10.4161/trns.2.5.17725.
Abstract
TRIM24 (TIF1α), TRIM28 (TIF1β) and TRIM33 (TIF1γ) are related cofactors defining a subgroup of the tripartite motif (TRIM) superfamily comprising an N-terminal RING finger E3 ligase and a C-terminal PHD-Bromodomain chromatin interacting module. Increasing evidence highlights the important roles of these proteins as modulators of multiple signaling pathways during normal development and as tumor suppressors. The finding that they interact to form a multiprotein complex suggests new mechanisms to integrate multiple signaling pathways for tumor suppression.
摘要
TRIM24（TIF1α）、TRIM28（TIF1β）和TRIM33（TIF1γ）是相关的辅助因子，它们定义了一个包含N端RING指E3连接酶和C端PHD-溴结构域染色质相互作用模块的三联基序（TRIM）超家族亚组。越来越多的证据表明，这些蛋白质在正常发育过程中作为多种信号通路的调节因子以及作为肿瘤抑制因子发挥着重要作用。它们相互作用形成多蛋白复合物这一发现提示了整合多种信号通路以实现肿瘤抑制的新机制。
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