探索TRIM家族在胃肠道癌中的作用机制、生物标志物及治疗靶点
Exploring the Mechanisms, Biomarkers, and Therapeutic Targets of TRIM Family in Gastrointestinal Cancer.
作者信息
Weng Chunyan, Jin Rijuan, Jin Xiaoliang, Yang Zimei, He Chenghai, Zhang Qiuhua, Xu Jingli, Lv Bin
机构信息
Department of Gastroenterology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, Zhejiang Province, People's Republic of China.
Department of Gastroenterology, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, Zhejiang Province, People's Republic of China.
出版信息
Drug Des Devel Ther. 2024 Dec 5;18:5615-5639. doi: 10.2147/DDDT.S482340. eCollection 2024.
Gastrointestinal region (GI) cancers are closely linked to the ubiquitination system, with the E3 ubiquitin ligase playing a crucial role by targeting various substrates. As E3 ubiquitin ligases, proteins of tripartite motif (TRIM) family play a role in cancer signaling, development, apoptosis, and formation. These proteins regulate diverse biological activities and signaling pathways. This study comprehensively outlines the functions of TRIM proteins in gastrointestinal physiology, contributing to our knowledge of the molecular pathways involved in gastrointestinal tumors. Gastrointestinal region (GI) cancers are closely linked to the ubiquitination system, with the E3 ubiquitin ligase playing a crucial role by targeting various substrates.
胃肠道（GI）癌症与泛素化系统密切相关，E3泛素连接酶通过靶向各种底物发挥关键作用。作为E3泛素连接酶，三联基序（TRIM）家族蛋白在癌症信号传导、发展、凋亡和形成中发挥作用。这些蛋白调节多种生物活性和信号通路。本研究全面概述了TRIM蛋白在胃肠道生理学中的功能，有助于我们了解胃肠道肿瘤相关的分子途径。胃肠道（GI）癌症与泛素化系统密切相关，E3泛素连接酶通过靶向各种底物发挥关键作用。
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