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贝司他汀用于切除的肺癌。一项随机临床试验。

Bestatin in resected lung cancer. A randomized clinical trial.

作者信息

Yasumitsu T, Ohshima S, Nakano N, Kotake Y, Tominaga S

机构信息

Department of Surgery, Osaka Prefectural Habikino Hospital, Japan.

出版信息

Acta Oncol. 1990;29(6):827-31. doi: 10.3109/02841869009093009.

DOI:10.3109/02841869009093009
PMID:2223157
Abstract

A randomized study with and without bestatin, a new biological response modifier, was conducted in order to evaluate its survival effect on resected lung cancer. A total of 153 patients (72 with squamous cell carcinoma, 66 with adenocarcinoma, and 15 with other types of cancer) were evaluated. Among the patients with squamous cell carcinoma, the bestatin-treated group had significantly prolonged survival compared to the control group. No significant difference between the two groups was seen in adenocarcinoma.

摘要

为了评估一种新型生物反应调节剂贝司他汀对切除的肺癌患者的生存影响,进行了一项有或没有贝司他汀的随机研究。总共评估了153例患者(72例鳞状细胞癌、66例腺癌和15例其他类型癌症)。在鳞状细胞癌患者中,与对照组相比,贝司他汀治疗组的生存期显著延长。腺癌患者两组之间未见显著差异。

相似文献

1
Bestatin in resected lung cancer. A randomized clinical trial.贝司他汀用于切除的肺癌。一项随机临床试验。
Acta Oncol. 1990;29(6):827-31. doi: 10.3109/02841869009093009.
2
Combination therapy with bestatin in inoperable lung cancer. A randomized trial.不可切除肺癌中联合使用贝司他汀的治疗:一项随机试验。
Acta Oncol. 1990;29(6):821-5. doi: 10.3109/02841869009093008.
3
Randomized double-blind placebo-controlled trial of bestatin in patients with resected stage I squamous-cell lung carcinoma.对已切除的Ⅰ期肺鳞状细胞癌患者进行的关于抑氨肽酶B的随机双盲安慰剂对照试验。
J Natl Cancer Inst. 2003 Apr 16;95(8):605-10. doi: 10.1093/jnci/95.8.605.
4
[Clinical evaluation of bestatin (NK-421) supplementing radiotherapy in the treatment of lung cancer].
Nihon Gan Chiryo Gakkai Shi. 1983 Aug 20;18(5):1175-80.
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[Double blind controlled study of ubenimex (Bestatin) against squamous cell lung cancer--a multicenter cooperative study].乌苯美司(抑氨肽酶B)治疗肺鳞状细胞癌的双盲对照研究——一项多中心合作研究
Gan To Kagaku Ryoho. 1993 Jul;20(9):1187-94.
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Bestatin as adjuvant treatment in operated stage I and stage II non-small cell lung cancer. European Lung Cancer Study Group.贝司他汀作为Ⅰ期和Ⅱ期非小细胞肺癌手术辅助治疗。欧洲肺癌研究组。
Acta Oncol. 1990;29(6):817-20. doi: 10.3109/02841869009093007.
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[Postoperative adjuvant immunochemotherapy with bestatin for stomach cancer. Randomized controlled trial: first report].[胃癌术后使用贝司他汀的辅助免疫化疗。随机对照试验:首次报告]
Gan To Kagaku Ryoho. 1985 Jul;12(7):1458-64.
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[Phase III controlled studies of bestatin in malignant tumors of the skin--results of treatment of squamous cell carcinoma and genital Paget's disease].[抑氨肽酶B治疗皮肤恶性肿瘤的III期对照研究——鳞状细胞癌和生殖器佩吉特病的治疗结果]
Gan To Kagaku Ryoho. 1985 Jun;12(6):1260-6.
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Postoperative adjuvant cisplatin, vindesine, plus uracil-tegafur chemotherapy increased survival of patients with completely resected p-stage I non-small cell lung cancer.术后辅助顺铂、长春地辛联合替加氟尿嘧啶化疗可提高完全切除的Ⅰ期非小细胞肺癌患者的生存率。
Lung Cancer. 2005 Jul;49(1):85-94. doi: 10.1016/j.lungcan.2004.11.025.
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[Randomized controlled trial of postoperative adjuvant chemotherapy with bestatin for gastric cancer].[胃癌术后用抑氨肽酶B进行辅助化疗的随机对照试验]
Gan To Kagaku Ryoho. 1985 Jan;12(1):125-33.

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