评估认知衰退的行为模型。
Behavioral model for assessing cognitive decline.
作者信息
Guidi Michael, Foster Thomas C
机构信息
Max Planck Institute of Psychiatry, Proteomics, and Biomarkers, Munich, Germany.
出版信息
Methods Mol Biol. 2012;829:145-53. doi: 10.1007/978-1-61779-458-2_8.
Abstract
The water maze task can be used to assess sensory motor and cognitive function in rodents. When properly employed, this task can behaviorally assess acquisition of a spatial search strategy, as well as working and reference memory. The following section uses research on age-related, cognitive decline to illustrate the methods employed and highlight areas that can, if not properly controlled, confound a study.
摘要
水迷宫任务可用于评估啮齿动物的感觉运动和认知功能。如果使用得当，该任务可以从行为学角度评估空间搜索策略的习得情况，以及工作记忆和参考记忆。以下部分将通过与年龄相关的认知衰退研究来说明所采用的方法，并强调一些若控制不当可能会混淆研究结果的领域。
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